Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).

Minerva B is a small rocky planet just like earth, where spacecraft Artemis has found water, organic molecules, and complex creatures. Is there something more to find?
'I am the mind of the spaceship, alone among the stars. 50 years ago, from a planet far away, the planet you call home, I launched. A journey of 28 trillion miles across the yawning time of space to the exoplanet, Minerva B: a small, rocky planet, much like Earth, but orbiting another sun. Here, I have found water, organic molecules, and microorganisms. When the news of my discovery reaches Earth years from now, some of you will be amazed. But others will remain unsatisfied, and you will ask, have I not found animals or birds? Have I not met intelligent life like us? And so, my search continues. I will find life of marvellous complexity, and the traces of a devastating loss.'

For decades, scientists have dreamed of finding life on Mars. But despite their best efforts, no signs of life have been found. Could that be about to change? This is the story of the scientists and engineers behind Perseverance: the rover that could change our view of Mars forever.