Over a person's lifetime they are likely to be prescribed more than 14,000 pills. Antibiotics, cholesterol lowering tablets, anti-depressants, painkillers, even tablets to extend youth and improve performance in bed. These drugs perform minor miracles day after day, but how much is really known about them? Drug discovery often owes as much to serendipity as to science, and that means much is learnt about how medicines work, or even what they do, when they're taken. By investigating some of the most popular pills people pop, Horizon asks, how much can they be trusted to do what they are supposed to?

From the makers of Walking With Dinosaurs comes an epic and entertaining new exploration of early life on Earth, revealing that before the age dinosaurs, a succession of fantastical animals and plants ruled the planet. A time when a two-ton predatory fish came on land to hunt, when four-metre sea scorpions sliced sushi in the shallows and when just one species of lumbering reptile represented 80 per cent of all life. For the first time, this special two-hour presentation uncovers and recreates these creatures and the bizarre world they inhabited.

Planet Earth is quite simply the greatest nature/wildlife series ever produced. The ultimate portrait of our planet looks at the key factors that shape our natural history. The sun and fresh water dominate the lives of all animals and plants on Earth and trigger seasonal migrations, small and large.

As almost all animal inhabitants of Antarctica are forced to migrate north, the sea underneath the frozen ice still provides a home to many specially adapted fish whose cells are protected from freezing through an 'antifreeze' liquid. Many of them feed on the faeces of other animals. The most notable larger animal that does not migrate north is perhaps the Weddell Seal, which can be found as close as 1300 kilometres to the pole. Groups of seals tear holes into the ice to dive for food and come up to breathe. The females come back to the ice to give birth. This episode also describes primitive plant life such as lichen, which can still be found on the continent in winter, even in the extremely dry and permanently frozen valleys conditions under which dead animals can lie frozen for many centuries without decomposing. It details the life of the Emperor Penguin, 'the only birds to lay their eggs directly on ice'. While other animals retreat, Emperors migrate not just to the ice, but into the Antarctic continent. The females lay eggs which are incubated by the males under the harshest conditions on Earth (huddling closely together for warmth), while the females return to the sea.

Rivers provide the essentials of life: fresh food and water. They often provide natural highways and enable us to live in just about every environment on Earth. But rivers can also flood, freeze or disappear altogether!Cities - Surviving the Urban Jungle Human Planet joins Sam Niang, a Laotian fisherman, as he walks a high wire strung above the raging Mekong River rapids on an extraordinary commute to work. There's also a look at the remarkable partnership between Samburu tribesmen and wild elephants in their search for water in the dried-out river beds of Northern Kenya. Plus, a father who must take his two children on a six-day trek down a frozen river - the most dangerous school run on Earth, and the ice dam busters of Ottowa with their dynamite solution to a city centre hold-up.

This episode of the documentary series focuses on the new giants, the heavyweights of the dinosaur world. It is only in recent years that experts have unearthed the biggest dinosaurs that ever lived. One monster eclipsed all others; more than seven times as heavy as diplodocus was the immense argentinosaurus - a single backbone was bigger than a human. For years, these giants were considered immune to attack from any predator - until the discovery of mapusaurus, a new giant killer whose fate appeared to be inextricably linked to argentinosaurus