An epic documentary film in which nine scientists will meet in a chain of encounters to uncover unexpected answers to some of humanity's biggest questions. How did life begin? What is time? What is consciousness? How much do we really know? By introducing researchers from diverse backgrounds for the first time, then dropping them into new, immersive field work they previously hadn't tackled, the film reveals the true potential of interdisciplinary collaboration, pushing the boundaries of how science storytelling is approached.
What emerges is a deeply human trip to the foundations of discovery and a powerful reminder that the unanswered questions are the most crucial ones to pose. The Most Unknown is an ambitious look at a side of science.

Valeant Pharmaceuticals was a multinational specialty pharmaceutical company based in Canada. It grew rapidly through a series of mergers and acquisitions under the leadership of J. Michael Pearson. The company was involved in a number of controversies surrounding drug price hikes and the use of a specialty pharmacy for the distribution of its drugs, which led to an investigation by the U.S. Securities and Exchange Commission and caused its stock price to plummet more than 90 percent from its peak while its debt surpassed $30 billion.
Wall Street short-sellers exposed a scam that regulators overlook: how Big Pharma gouges patients in need of life-saving drugs.

Autistic minds provide windows into how we all think, feel, and behave. A complete brain science should be able to account for all kinds of minds and brains. As long as some minds remain a mystery, so too will all minds.
Michael Stevens travels to London to meet a blind, autistic savant with astonishing musical abilities, and volunteers to have his brain's function temporarily disrupted at UCLA's Neuromodulation Lab.

The nervous system is fundamentally electric. When we move our arm, it moves because a electric signal has been sent to the muscle that controls it. Now, because the brain is electric, we could also use electricity to record what the brain is doing or bypass it entirely, and control a body. That means that we could restore movement to people who are paralyzed, feel through an artificial hand as if it was our own, and even read people's minds.
Michael Stevens explores how electricity can be used to move cockroaches, control other peoples' limbs and even read peoples' thoughts.

Years after he changed the landscape of filmmaking with The Exorcist, filmaker and writer William Friedkin moves from fiction to fact with this documentary. What began as a brief conversation between Friedkin and Father Gabrielle Amorth - the head Exorcist for the Diocese of Rome for over 30 years - as two professionals who knew of each other's work, soon transformed into an once-in-a-lifetime opportunity, as Amorth agreed Friedkin could film an exorcism ceremony. It would be the ninth exorcism for a painfully afflicted woman, and it would be filmed by Friedkin alone, with no other crew allowed, no light other than the natural light in the room and a small digital camera-and-mic unit that could capture the ritual and its revelations.
Combining the startling and singular footage from Cristina's exorcism with interviews from priests and psychologists, neurosurgeons and non-believers, Friedkin guides us on a journey into the twilight world between the boundaries of what we know and what we don't.

The film tells the story of an overlooked genius: Claude Shannon. In a blockbuster paper in 1948, Claude Shannon introduced the notion of a 'bit' and laid the foundation for the information age. His ideas ripple through nearly every aspect of modern life, influencing such diverse fields as communication, computing, cryptography, neuroscience, artificial intelligence, cosmology, linguistics, and genetics. But when interviewed in the 1980s, Shannon was more interested in showing off the gadgets he'd constructed -- juggling robots, a Rubik's Cube solving machine, a wearable computer to win at roulette, a unicycle without pedals, a flame-throwing trumpet -- than rehashing the past.
Mixing contemporary interviews, archival film, animation and dialogue drawn from interviews conducted with Shannon himself, The Bit Player tells the story of an overlooked genius who revolutionized the world, but never lost his childlike curiosity.