One hundred years after Columbus' arrival in the Caribbean, Spanish Conquistadors and Priests, push into North America in search of gold and to spread Catholicism. With the arrival of the British in North America, the two colonial systems produce contrasting societies that come in conflict as Manifest Destiny pushes the U.S into the Mexican territories of the South West. As the Gold Rush floods California with settlers, complex and vital communities are overwhelmed. The elites, including Mariano Vallejo and Apolinaria Lorenzana lose their land. Mexicans and Mexican Americans are treated as second-class citizens, facing discrimination and racial violence. Resistance to this injustice appears in New Mexico as Las Gorras Blancas (The White Caps), burn Anglo ranches and cut through barbed wire to prevent Anglo encroachment. At the same time, New Mexicans manage to transform themselves through education, managing to preserve Hispano culture in New Mexico and their standing in the midst of an era of conquest and dispossession.

Widespread immigration to the U.S. from Latin countries begins – first with a small group from Cuba, then a larger one from Mexico. Both flee chaos and violence in their home country and are attracted by opportunities in the United States. In 1898, the U.S. helps liberate Cuba and Puerto Rico from Spain but then seizes Puerto Rico as its colony. The first Puerto Rican arrivals (now U.S. citizens) establish a network in New York.

World War II is a watershed event for Latino Americans with hundreds of thousands of men and women serving in the armed forces, most fighting side by side with Anglos. In the Pacific, East L.A.'s Guy Gabaldon becomes a Marine Corp legend when he singlehandedly captures more enemy soldiers than anyone in US military history. But on the home front, discrimination is not dead: in 1943, Anglo servicemen battle hip young "Zoot suitors" in racially charged riots in southern California

Until World War II, Latino immigration to the United States was overwhelmingly Mexican-American. Now three new waves bring large-scale immigration from Puerto Rico, Cuba, and the Dominican Republic. As the Puerto Rican government implements a historic overhaul over a million Puerto Ricans are encouraged to leave for the US mainland, to alleviate the economic pressure. A young Juanita Sanabria arrives in New York, works hard in the garment district, but encounters hostility and discrimination. Ethnic tensions explode in youth gang warfare depicted in films like West Side Story, etching the stereotype of the knife wielding Puerto Rican in the American consciousness.

In the 1960s and 1970s a generation of Mexican Americans, frustrated by persistent discrimination and poverty, find a new way forward, through social action and the building of a new "Chicano" identity. The movement is ignited when farm workers in the fields of California, led by Cesar Chavez and Dolores Huerta, march on Sacramento for equal pay and humane working conditions. Through plays, poetry and film, Luis Valdez and activist Corky Gonzalez create a new appreciation of the long history of Mexicans in the South West and the Mestizo roots of Mexican Americans. In Los Angeles, Sal Castro, a schoolteacher, leads the largest high school student walkout in American history, demanding that Chicano students be given the same educational opportunities as Anglos. In Texas, activists such as Jose Angel Gutierrez, create a new political party and change the rules of the electoral game. By the end of the 1970s Chicanos activism and identity have transformed what it means to be an American. Chicano and Latino studies are incorporated into school curriculum; Latinos are included in the political process.

In the 80s the nature of the Latino Diaspora changes again. From Cuba a second wave of refugees to United States – the Mariel exodus – floods Miami . The same decade sees the sudden arrival of hundreds of thousands of Central Americans (Salvadorans, Guatemalans, and Nicaraguans) fleeing death squads and mass murders at home like activist, Carlos Vaquerano. By the early 1990s, a political debate over illegal immigration – has begun. Globalization, empowered by NAFTA, means that as U.S. manufacturers move south, Mexican workers head north in record numbers. A backlash ensues: tightened borders, anti-bilingualism, state laws to declare all illegal immigrants felons. But a sea change is underway: the coalescence of a new phenomenon called Latino American culture-as Latinos spread geographically and make their mark in music, sports, politics, business, and education.