How to Talk to Aliens

Where is everyone? We have been listening for messages from outer space for more than half a century, and so far... silence, why? Are we truly alone in the universe? Or is everyone else acting like us and just doing a lot of listening? Maybe we need to be louder. Maybe we need to send more messages out there. But how do you write a letter to an extraterrestrial whose language and culture and biology and mind we have no concept of? And what do you say?
Given all of the unknowns about what they might behave, should we say anything at all?