There is a strange and mysterious world that surrounds us, a world largely hidden from our senses. The quest to explain the true nature of reality is one of the great scientific detective stories. Clues have been pieced together from deep within the atom, from the event horizon of black holes, and from the far reaches of the cosmos. It may be that we are part of a cosmic hologram, projected from the edge of the universe. Or that we exist in an infinity of parallel worlds. Your reality may never look quite the same again.

The story of how the secret of life has been examined through the prism of the most complex organism known - the human body. It begins with attempts to save the lives of gladiators in Ancient Rome, unfolds with the macabre work and near-perfect drawings of Leonardo in the Renaissance, through the idea of the 'life force' of electricity, to the microscopic world of the cell. It reveals how a moral crisis unleashed by work on the nuclear bomb helped trigger a great breakthrough in biology - understanding the structure and workings of DNA.

This series takes viewers on a journey to the frontiers of science, where researchers are tackling some of the biggest questions about life and the cosmos. The universe is hiding something. In fact, it is hiding a lot. Everything we experience on Earth, the stars and galaxies we see in the cosmos—all the 'normal' matter and energy that we understand—make up only 5% of the known universe. The other 95% is made up of two mysterious components: 'dark matter' and 'dark energy.' We can’t see them, but we know they’re there. And what’s more —these two shadowy ingredients are locked in an epic battle to control the very fate of the universe.
Now, scientists are trying to shed light on the so-called 'dark sector' as the latest generation of detectors rev up, and powerful telescopes peer deeper into space than ever before to observe how it behaves. Will the discoveries help reveal how galaxies formed? In the series finale, Nova Wonders journeys to the stars and back to investigate what we know —and don’t know. Find out how scientists are discovering new secrets about the history of the universe, and why they’re predicting a shocking future.

Time i s a concept which is so familiar, and yet recent discoveries have revealed it to be far stranger than we could have possibly imagined. In the final programme in the series, Brian explores the enigma of time - a phenomenon we take for granted but which is one of the biggest mysteries in the universe. He recalls highlights from his TV series that touch upon this conundrum.

We float along the river of time. But does that river have a source? Where did time come from? Some believe time and space are one thing, and the Big Bang started the cosmic clock. Others believe the universe existed for almost half a million "years" before light could move and time began. Still others say time is older than our universe. But what if time itself is an illusion? Incredible new experiments may hold the answer. One groundbreaking experiment gives us the power to punch holes in time…and another may create a machine that operates outside time’s boundaries!

The episode begins with Tyson describing how pattern recognition manifested in early civilization as using astronomy and astrology to predict the passing of the seasons, including how the passage of a comet was often taken as an omen. Tyson continues to explain that the origin of comets only became known in the 20th century due to the work of Jan Oort and his hypothesis of the Oort cloud. Tyson then continues to relate the collaboration between Edmond Halley and Isaac Newton in the last part of the 17th century in Cambridge. The collaboration would result in the publication of Philosophiæ Naturalis Principia Mathematica, the first major work to describe the laws of physics in mathematical terms, despite objections and claims of plagiarism from Robert Hooke and financial difficulties of the Royal Society of London. Tyson explains how this work challenged the prevailing notion that God had planned out the heavens, but would end up influencing many factors of modern life, including space flight. Tyson further describes Halley's contributions including determining Earth's distance to the sun, the motion of stars and predicting the orbit of then-unnamed Halley's Comet using Newton's laws. Tyson contrasts these scientific approaches to understanding the galaxy compared to what earlier civilizations had done, and considers this advancement as mankind's first steps into exploring the universe. The episode ends with an animation of the Milky Way and Andromeda galaxies' merging based on the principles of Newton's laws.