Our galaxy is one of hundreds of billions in the universe. View of universe through the Hubble telescope and go back almost all the way to the Big Bang.

Carl Sagan opens the program with a description of the cosmos and the Spaceship of the Imagination. The ship journeys through the universe's hundred billion galaxies, the Local Group, the Andromeda Galaxy, the Milky Way, the Orion Nebula, our Solar System, and finally the planet Earth. Eratosthenes' successful calculation of the circumference of Earth leads to a description of the ancient Library of Alexandria. Finally, the Ages of Science are described, before pulling back to the full span of the Cosmic Calendar.

Famed astrophysicist Neil deGrasse Tyson takes a tour of the Solar System and the known universe establishing the components of Earth's "address" within the Virgo Supercluster. He then shares the story of the person who championed an expansive understanding of Earth's place in the universe by presenting Renaissance Italian Giordano Bruno's vision of the universe as a limitless expanse of space and time. He then makes an exploration into the Cosmic Calendar, which dates back to the dawn of the Big Bang (similar to the presentation from episode 1 of the original series). The episode ends with deGrasse Tyson narrating how he met his mentor Carl Sagan, who hosted the first Cosmos series.

We're unlocking the secrets of our planet's voyage and discovering that earth's journey affects us all. The Earth is extremely dynamic. It is spinning on its axis, it's whirling about the sun and it's corkscrewing throughout the this galaxy. And there is the fact than Andromeda and the Milky Way are currently 2.5 million light-years apart, but they're hurtling towards each other at over 250,000 miles an hour. A collision is inevitable. As stars, dust, and gas swirl around each other, gravitational interactions could slingshot our solar system out into intergalactic space.

Questions are raised about the search for intelligent life beyond the Earth, with UFOs and other close encounters refuted in favor of communications through SETI and radio telescope such as the Arecibo Observatory. The probability of technically advanced civilizations existing elsewhere in the Milky Way is interpreted using the Drake equation and a future hypothetical Encyclopedia Galactica is discussed as a repository of information about other worlds in the galaxy. The Cosmos Update notes that there have been fewer sightings of UFOs and more stories of abductions, while mentioning the META scanning the skies for signals.

The Milky Way, our galaxy, is a magnificent sight in the night sky, but we know surprisingly little about it for certain. What is its shape? How many stars does it actually contain? What lies at its centre? The Gaia space telescope will answer these questions, being armed with the most advanced camera to leave our planet, and it will allow us to see our galaxy as we've never seen it before. The Sky at Night visits the factory in Chelmsford that made the astonishing sensor at the heart of the mission.