Michael Mosley has set himself a truly ambitious goal: he wants to live longer, stay younger and lose weight in the bargain. And he wants to make as few changes to his life as possible along the way. He discovers the powerful new science behind the ancient idea of fasting, and he thinks he's found a way of doing it that still allows him to enjoy his food. Michael tests out the science of fasting on himself - with life-changing results.

Chris turns to longevity doctor Peter Attia to find out how changing his eating habits can help his quest for longevity. Ironically, the answer is to eat no food at all for four long days. If he can bear the hunger, fasting will unlock his body’s own anti-aging powers and give Chris the edge he needs when he tries to hunt for his next meal … by spearfishing off the Great Barrier Reef.

The episode is a journey through the human gut and the process of turning food into energy to keep the body going. Humans have turned eating into culture, a way to celebrate our roots, to bring us together. But food is really just one thing: Fuel. It's where you get the power to live your life. Even when you're sitting completely still, your body needs a lot of energy to stay on. But nowhere is the need for fuel more apparent than when you push yourself to the absolute limit. And the microbiome, the bacteria living in our gut, plays a great role in all this.

The human brain is the most complex object we’ve discovered in the universe, and every day much of its neural circuitry is taken up with the tens of thousands of decisions we need to make. ‘How do I decide?’ is a journey through the unseen world of decisions, and how they get made. Decisión-making is what allows us to navigate a course through life. Discover how important emotions are in making decissions and, as we learn more about our own brains, we can break away from slavery to our impulses. Neuroscience shows that you're made up of multiple competing drives and by understanding how choices battle it out in the brain, we can learn how to make better decisions.

Angela Rippon and Dr Chris van Tulleken travel the world in search of the latest science that could help us all stay young and healthy for longer. They investigate the best ways to help both our bodies and brains age better. Up first is the body, and Angela travels to Germany to join a groundbreaking study which reveals the exercise that holds off ageing the most. Chris visits America to find out about the unexpected diet that can add years to our lives. And in Ecuador we meet a seventeen-year-old who looks like a child to discover how scientists hope he may hold the key to preventing the diseases of ageing.

This episode explores what can give brains a boost. In America, Angela tries out a new treatment that's proven to help memory and concentration. In Japan, a remarkable 100-year-old reveals the colourful foods that keep minds more active. Plus Chris discovers the best exercise we can do for our brains. At the cutting-edge of science, discover how injections of young people's blood may help beat dementia.