The episode begins with Tyson describing how pattern recognition manifested in early civilization as using astronomy and astrology to predict the passing of the seasons, including how the passage of a comet was often taken as an omen. Tyson continues to explain that the origin of comets only became known in the 20th century due to the work of Jan Oort and his hypothesis of the Oort cloud. Tyson then continues to relate the collaboration between Edmond Halley and Isaac Newton in the last part of the 17th century in Cambridge. The collaboration would result in the publication of Philosophiæ Naturalis Principia Mathematica, the first major work to describe the laws of physics in mathematical terms, despite objections and claims of plagiarism from Robert Hooke and financial difficulties of the Royal Society of London. Tyson explains how this work challenged the prevailing notion that God had planned out the heavens, but would end up influencing many factors of modern life, including space flight. Tyson further describes Halley's contributions including determining Earth's distance to the sun, the motion of stars and predicting the orbit of then-unnamed Halley's Comet using Newton's laws. Tyson contrasts these scientific approaches to understanding the galaxy compared to what earlier civilizations had done, and considers this advancement as mankind's first steps into exploring the universe. The episode ends with an animation of the Milky Way and Andromeda galaxies' merging based on the principles of Newton's laws.

We now know that the brain - the organ that more than any other makes us human - is one of the wonders of the universe, and yet until the 17th century it was barely studied. The twin sciences of brain anatomy and psychology have offered different visions of who we are. Now these sciences are coming together and in the process have revealed some surprising and uncomfortable truths about what really shapes our thoughts, feelings and desires. And the search to understand how our brains work has also revealed that we are all - whether we realise it or not - carrying out science from the moment we are born.

Black Holes are one of the most destructive forces in the universe, capable of tearing a planet apart and swallowing an entire star. Yet scientists now believe they could hold the key to answering the ultimate question - what was there before the Big Bang? The trouble is that researching them is next to impossible. Black holes are by definition invisible and there's no scientific theory able to explain them. Meet the astronomers attempting to image a black hole for the very first time and the theoretical physicists getting ever closer to unlocking their mysteries. It's a story that takes us into the heart of a black hole and to the very edge of what we think we know about the universe.

‘Who Is in Control?’ explores the great deception that greets us each morning when we awake: it feels as though we are in conscious control of our lives but the truth is that we are not. Instead almost every action, every decision, every belief that we hold is driven by parts of the brain that we have no access to.

The world is affected by an obesity epidemic, but why is it that not everyone is succumbing? Medical science has been obsessed with this subject and is coming up with some unexpected answers. As it turns out, it is not all about exercise and diet. At the centre of this programme is a controversial overeating experiment that aims to identify exactly what it is about some people that makes it hard for them to bulk up.

The world stood in fear of an emerging new disease that threatened to kill millions. A new flu variant H1N1 had arrived. If this latest pandemic has taught anything, it is just how little is understood about the invisible world of viruses. But that has not stopped scientists trying. Horizon follows the leading researchers from across the world, who are attempting to unravel the many secrets of viruses to understand when and why they kill.