Beginning with the origins of the universe in the Big Bang, Sagan describes the formation of different types of galaxies and anomalies such as galactic collisions and quasars. The episodes moves further into ideas about the structure of the Universe, such as different dimensions (in the imaginary Flatland and four-dimensional hypercubes), an infinite vs. a finite universe, and the idea of an oscillating Universe (similar to that in Hindu cosmology). The search into other ideas such as dark matter and the multiverse is shown, using tools such as the Very Large Array in New Mexico. Cosmos Update shows new information about the odd, irregular surfaces of galaxies and the Milky Way perhaps being a barred spiral galaxy

This episode provides an overview of the nature of electromagnetism, as discovered through the work of Michael Faraday. Tyson explains how the idea of another force of nature, similar to gravitational forces, had been postulated by Isaac Newton before. Tyson continues on Faraday, coming from poor beginnings, would end up becoming interested in studying electricity after reading books and seeing lectures by Humphry Davy at the Royal Institution. Davy would hire Faraday after seeing extensive notes he had taken to act as his secretary and lab assistant. After Davy and chemist William Hyde Wollaston unsuccessfully tried to build on Hans Christian Ørsted's discovery of the electromagnetic phenomena to harness the ability to create motion from electricity, Faraday was able to create his own device to create the first electric motor by applying electricity aligned along a magnet. Davy, bitter over Faraday's breakthrough, put Faraday on the task of improving the quality of high-quality optical glass, preventing Faraday from continuing his research. Faraday, undeterred, continued to work in the Royal Institution, and created the Christmas Lectures designed to teach science to children. Following Davy's death, Faraday returned to full time efforts studying electromagnetism, creating the first electrical generator by inserting a magnet in a coil of wires. Tyson continues to note that despite losing some of his mental capacity, Faraday concluded that electricity and magnetism were connected by unseen fields, and postulated that light may also be tied to these forces. Using a sample of the optical glass that Davy had him make, Faraday discovered that an applied magnetic field could affect the polarization of light passing through the glass sample (a dielectric material), leading to what is called the Faraday effect and connecting these three forces. Faraday postulated that these fields existed across the planet, which would later by called Earth's magnetic field generated by the rotating molten iron inner core, as well as the phenomena that caused the planets to rotate around the sun. Faraday's work was initially rejected by the scientific community due to his lack of mathematical support, but James Clerk Maxwell would later come to rework Faraday's theories into the Maxwell's equations that validated Faraday's theories. Their combined efforts created the basis of science that drives the principles of modern communications today.

The second episode takes a look at how humans have always been voyagers and explorers, leaving the comfort of native shores to explore. Neil DeGrasse Tyson will show us a long-term vision of humanity's future worlds.

This episode covers the nature of how life may have developed on Earth and the possibility of life on other planets. Tyson begins by explaining how the human development of writing systems enabled the transfer of information through generations, describing how Princess Enheduanna ca. 2280 BCE would be one of the first to sign her name to her works, and how Gilgamesh collected stories, including that of Utnapishtim documenting a great flood comparable to the story of Noah's Ark. Tyson explains how DNA similarly records information to propagate life, and postulates theories of how DNA originated on Earth, including evolution from a shallow tide pool, or from the ejecta of meteor collisions from other planets. In the latter case, Tyson explains how comparing the composition of the Nakhla meteorite in 1911 to results collected by the Viking program demonstrated that material from Mars could transit to Earth, and the ability of some microbes to survive the harsh conditions of space. With the motions of solar systems through the galaxy over billions of years, life could conceivably propagate from planet to planet in the same manner. Tyson then moves on to consider if life on other planets could exist. He explains how Project Diana performed in the 1960s showed that radio waves are able to travel in space, and that all of humanity's broadcast signals continue to radiate into space from our planet. Tyson notes that projects have since looked for similar signals potentially emanating from other solar systems. Tyson then explains that the development and lifespan of extraterrestrial civilizations must be considered for such detection to be realized. He notes that civilizations can be wiped out by cosmic events like supernovae, natural disasters such as the Toba disaster, or even self-destruct through war or other means, making probability estimates difficult. Tyson describes how elliptical galaxies, in which some of the oldest red dwarf stars exist, would offer the best chance of finding established civilizations. Tyson concludes that human intelligence properly applied should allow our species to avoid such disasters and enable us to migrate beyond the Earth before the Sun's eventual transformation into a red giant.

The simple act of making an apple pie is extrapolated into the atoms and subatomic particles (electrons, protons, and neutrons) necessary. Many of the ingredients necessary are formed of chemical elements formed in the life and deaths of stars (such as our own Sun), resulting in massive red giants and supernovae or collapsing into white dwarfs, neutron stars, pulsars, and even black holes. These produce all sorts of phenomena, such as radioactivity, cosmic rays, and even the curving of spacetime by gravity. Cosmos Update mentions the supernova SN 1987A and neutrino astronomy.

This episode explores the palaeogeography of Earth over millions of years, and its impact on the development of life on the planet. Tyson starts by explaining that the lignin-rich trees evolved in the Carboniferous era about 300 million ago, then explains on the nature of plate tectonics that would shape the landmasses of the world and the asteroid impact that initiated the Cretaceous–Paleogene extinction event, leaving small mammals as the dominate species on earth. Earth's landmasses are expected to change in the future and postulates what may be the next great extinction event.