Horizon investigates the idea that the best way to lose weight successfully is a personalised approach, diets tailored to our individual biology and psychology. In a groundbreaking experiment, Dr Chris van Tulleken and Tanya Byron join a team of experts to put 75 overweight volunteers on diets designed to tackle the specific reasons why they eat too much. The volunteers are put through a series of tests at a residential clinic to understand how their genes, hormones and psychology influence their eating behaviour. They are then put on the diets the experts believe are best suited to them. Can science succeed where other diets have failed?

The story of how the secret of life has been examined through the prism of the most complex organism known - the human body. It begins with attempts to save the lives of gladiators in Ancient Rome, unfolds with the macabre work and near-perfect drawings of Leonardo in the Renaissance, through the idea of the 'life force' of electricity, to the microscopic world of the cell. It reveals how a moral crisis unleashed by work on the nuclear bomb helped trigger a great breakthrough in biology - understanding the structure and workings of DNA.