This episode covers the nature of how life may have developed on Earth and the possibility of life on other planets. Tyson begins by explaining how the human development of writing systems enabled the transfer of information through generations, describing how Princess Enheduanna ca. 2280 BCE would be one of the first to sign her name to her works, and how Gilgamesh collected stories, including that of Utnapishtim documenting a great flood comparable to the story of Noah's Ark. Tyson explains how DNA similarly records information to propagate life, and postulates theories of how DNA originated on Earth, including evolution from a shallow tide pool, or from the ejecta of meteor collisions from other planets. In the latter case, Tyson explains how comparing the composition of the Nakhla meteorite in 1911 to results collected by the Viking program demonstrated that material from Mars could transit to Earth, and the ability of some microbes to survive the harsh conditions of space. With the motions of solar systems through the galaxy over billions of years, life could conceivably propagate from planet to planet in the same manner. Tyson then moves on to consider if life on other planets could exist. He explains how Project Diana performed in the 1960s showed that radio waves are able to travel in space, and that all of humanity's broadcast signals continue to radiate into space from our planet. Tyson notes that projects have since looked for similar signals potentially emanating from other solar systems. Tyson then explains that the development and lifespan of extraterrestrial civilizations must be considered for such detection to be realized. He notes that civilizations can be wiped out by cosmic events like supernovae, natural disasters such as the Toba disaster, or even self-destruct through war or other means, making probability estimates difficult. Tyson describes how elliptical galaxies, in which some of the oldest red dwarf stars exist, would offer the best chance of finding established civilizations. Tyson concludes that human intelligence properly applied should allow our species to avoid such disasters and enable us to migrate beyond the Earth before the Sun's eventual transformation into a red giant.

The film documents the historic journey of a team of adventurers as they strive to complete the world's first completely human powered ocean row from Cape Horn to the Antarctic Peninsula across The Drake Passage, the most dangerous 600 miles of open ocean on Earth.
The expedition was captained by Icelandic explorer Fiann Paul, who was joined by a team of six record-holding explorers and athletes from four nations and three continents, including Colin O'Brady. The row pushes the entire crew to their limits, testing their physical and mental strength as they work to accomplish something many think was impossible.

Dr Alice Roberts re-traces the greatest ever journey taken by our ancestors. Thousands of years ago one small group of our species, Homo sapiens, crossed out of Africa and into the unknown. Their descendants faced baking deserts, sweat-soaked jungles and frozen wildernesses and risked everything on the vast empty ocean. Within 60,000 years they colonised the whole world... How did they do it? Why do we, their descendants all look so different?

Alice Roberts tries to find out how Stone Age people reached North and South America for the first time. She finds out about an ancient corridor through the Canadian ice sheet that might have allowed the first humans through. Old finds in Chile though point to a whole different route for the first humans making it there.

The journey continues into Asia, the world's greatest land mass, in a quest to discover how early hunter-gatherers managed to survive in one of the most inhospitable places on earth - the Arctic region of Northern Siberia. Alice also explores what may have occurred during human migration to produce Chinese physical characteristics, and considers a controversial claim about Chinese evolution: that the Chinese do not share the same African ancestry as other peoples.

Dr Alice Roberts looks at our ancestors' seemingly impossible journey to Australia. Miraculously preserved footprints and very old human fossils buried in the outback suggest a mystery: that humans reached Australia almost before anywhere else. How could they have travelled so far from Africa, crossing the open sea on the way, and do it thousands of years before they made it to Europe? The evidence trail is faint and difficult to pick up, but Alice takes on the challenge. In India, new discoveries among the debris of a super volcano hint that our species started the journey much earlier than previously thought, while in Malaysia, genetics points to an ancient trail still detectable in the DNA of tribes today. Alice travels deep into the Asian rainforests in search of the first cavemen of Borneo and tests out a Stone Age raft to see whether sea travel would have been possible thousands of years ago, before coming to a powerful conclusion.