The documentary is to tell the dramatic story of the greatest natural disaster to shake the ancient world, a disaster that triggered the downfall of a civilisation and spawned a legend. Around 1620 BC a gigantic volcano in the Aegean Sea stirred from its 19,000-year slumber. The eruption tore the island of Thera apart, producing massive tsunamis that flooded the nearby island of Crete, the centre of Europe's first great civilisation – the Minoans. This apocalyptic event, many experts now believe, provided the inspiration for the legend of Atlantis. Based on the work of leading scientists, archaeologists and historians, this drama immerses viewers in the exotic world of the Minoans.

This documentary attempts to make history by finding the lost city of Atlantis once and for all. Adventurer-geologist Dr. Martin Pepper sets out to prove his theory – that the true Atlantis existed on the Greek island of Santorini, and was destroyed in the biggest volcanic eruption in human history". In order to achieve his goal, Pepper will use new scientific evidence gathered using state-of-the-art sonar scans of the sea bed and microscopic analysis of the ancient landscape. One of the challenges he faces is that he must also match Santorini to a series of key clues embedded in the first ever description of Atlantis by the Greek philosopher Plato – from the lost city’s strange ring-shaped design, to the role Egyptian priests played in recording the legend in the first place. His journey will take him across the Mediterranean and out into the Atlantic Ocean. By the end of the program, he reveals the stunning findings which may pinpoint the city and show exactly what it looked like.

The series, depicted by state of the art CGI techniques, and applying the laws of life on Earth to the rest of the galaxy, blends fact with science fiction and conceptualizes what alien life might be like on other planets.
In the prologue, astronomer Didier Queloz makes an appearance to discuss the discoveries of exoplanets and how they are analyzed in the real world. In Episode 1, the fictional world imagined is Atlas, a world with higher gravity than Earth and a thicker atmosphere leading to airborne creatures. In explaining the aliens of Atlas, the episode also explores the handicap principle in insects, and shows a rehabilitative form of falconry as captive falcons are trained to live in the wild.

The Dutch Golden Age saw map-making reach a fever pitch of creative and commercial ambition. This was the era of the first ever Atlases - elaborate, lavish and beautiful. This was the great age of discovery and marked an unprecedented opportunity for mapmakers who sought to record and categorise the newly acquired knowledge of the world. Rising above the many mapmakers in this period was Gerard Mercator, inventor of the Mercator projection, who changed mapmaking forever when he published his collection of world maps in 1598 and coined the term 'Atlas'. The programme looks at some of the largest and most elaborate maps ever produced, from the vast maps on the floor of the Royal Palace in Amsterdam, to the 24 volume atlas covering just the Netherlands, to the largest Atlas in the world, The Klencke Atlas. It was made for Charles II to mark his restoration in 1660. But whilst being one of the British Libraries most important items, it is also one of its most fragile so hardly ever opened. This is a unique opportunity to see inside this enormous and lavish work, and see the world through the eyes of a King.

Author and nuclear physicist Professor Jim Al-Khalili looks at what led to the discovery that everything is made of atoms. The programme looks at how the discovery affected the scientific world including the atomic energy theories of Albert Einstein and Werner Heisenberg and quantum mechanics

In the last in the series Professor Jim Al-Khalili explores how studying the atom forced us to rethink the nature of reality itself. He discovers that there might be parallel universes in which different versions of us exist, finds out that empty space isn't empty at all, and investigates the differences in our perception of the world in the universe and the reality.