An epic documentary film in which nine scientists will meet in a chain of encounters to uncover unexpected answers to some of humanity's biggest questions. How did life begin? What is time? What is consciousness? How much do we really know? By introducing researchers from diverse backgrounds for the first time, then dropping them into new, immersive field work they previously hadn't tackled, the film reveals the true potential of interdisciplinary collaboration, pushing the boundaries of how science storytelling is approached.
What emerges is a deeply human trip to the foundations of discovery and a powerful reminder that the unanswered questions are the most crucial ones to pose. The Most Unknown is an ambitious look at a side of science.

Until World War II, Latino immigration to the United States was overwhelmingly Mexican-American. Now three new waves bring large-scale immigration from Puerto Rico, Cuba, and the Dominican Republic. As the Puerto Rican government implements a historic overhaul over a million Puerto Ricans are encouraged to leave for the US mainland, to alleviate the economic pressure. A young Juanita Sanabria arrives in New York, works hard in the garment district, but encounters hostility and discrimination. Ethnic tensions explode in youth gang warfare depicted in films like West Side Story, etching the stereotype of the knife wielding Puerto Rican in the American consciousness.

Episode 7 focuses specifically on first contact and the search for intelligent life in the vastness of the cosmos. Are humans ready to make first contact with other intelligent beings? Is our technology even sophisticated enough to detect communication signals from another world? Who are we to search for alien intelligence when we can't even recognize or respect the consciousness all around us, or even beneath our feet.
Neil deGrasse Tyson reveals the hidden underground network that is a collaboration of four kingdoms of life, and a true first contact story between humans and beings who communicate in a symbolic language and have maintained a representative democracy for many tens of millions of years.

Professor Marcus du Sautoy goes in search of answers to one of science's greatest mysteries: how do we know who we are? While the thoughts that make us feel as though we know ourselves are easy to experience, they are notoriously difficult to explain. He has his mind scrambled by a cutting-edge experiment in anaesthesia. After, Marcus is given an out-of-body experience in a bid to locate his true self.

A single microscopic brain cell cannot think, is not conscious, but if you bring in a few more brain cells, and a few more, and connect them all, at a certain point, the group itself will be able to think and experience emotions and have opinions and a personality and know that it exists. How can such astonishing things be made from such simple ingredients? Well, answering that question means learning not only who we are but, more importantly, how we are.
Today, using what neuroscientists know so far, we are going to make a town function like a brain, using people as neurons.

'What Makes Me?', explores the question of how the brain gives rise to our thoughts, emotions, our memories and personality. Philosophers and great thinkers have for millennia pondered the question of how physical stuff can give rise to mental processes. Last century, the new field of neuroscience joined the discussion, and Dr David Eagleman explains that to a neuroscientist, the answers to such questions lie in a deep understanding of the brain.