40,000 years ago the steppes of Eurasia were home to our closest human relative, the Neanderthals. Recent genetic and archaeological discoveries have proven that they were not the dim-witted cave dwellers we long thought they were. In fact, they were cultured, technologically savvy and more like us than we ever imagined! So why did they disappear? We accompany scientists on an exciting search for an answer to this question and come to a startling conclusion... A climate change due to a cataclysmic event.

The theory of Némesis, a star that orbits the Sun and causes catastrophic events is explored. Nemesis is a hypothetical red dwarf or brown dwarf, originally postulated in 1984 to be orbiting the Sun at a distance of about 95,000 AU (1.5 light-years) somewhat beyond the Oort cloud, to explain a perceived cycle of mass extinctions in the geological record, which seem to occur more often at intervals of 26 million years.

The series takes place after the extinction of the dinosaurs 65 million years ago and recreates animals of the Cenozoic with computer-generated imagery and animatronics. The first episode starts 49 million years ago, when Earth has fully recovered from the dinosaur extinction and is covered in a mysterious forest. This is a time that the world has almost forgotten - Germany was a hot sweaty jungle, birds ruled the earth and preyed on miniature horses and whales walked on land.

Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).

In the third part of his journey into the history of Christianity, Professor Diarmaid MacCulloch charts Orthodoxy's extraordinary fight for survival. After its glory days in the eastern Roman Empire, it stood right in the path of Muslim expansion, suffered betrayal by crusading Catholics, was seized by the Russian tsars and faced near-extinction under Soviet communism. MacCulloch visits the greatest collection of early icons in the Sinai desert, a surviving relic of the iconoclastic crisis in Istanbul and Ivan the Terrible's cathedral in Moscow to discover the secret of Orthodoxy's endurance.

The sixth episode of the series narrates the fascinating story of the evolution and survival of life on our planet after the catastrophic event that marked the end of the era of dinosaurs, 66 million years ago. Through a visually stunning journey, we will see the impact of the meteorite and all its consequences in detail. We will also discover how the animals and plants that survived the mass extinction adapted, evolved, and diversified to fill the ecological niches left by the dinosaurs. From the first mammals and birds that emerged from the ashes to dominate the Earth, to the formation of complex ecosystems in the oceans and on land, the documentary offers a unique vision of the resilience and innovation of life on our planet.
With impressive imagery and exciting stories, it reveals how life, against all odds, thrived after one of the most devastating events in Earth's history. This documentary is a testament to the unbreakable strength of life and its ability to adapt and flourish even in the most adverse conditions.