The series follows the tragedy that occurred when terrorists attacked at the annual Boston Marathon on April 15, 2013. They carried out the attack by placing two homemade pressure cooker bombs which detonated near the finish line of the race 14 seconds and 210 yards (190 m) apart. That resulted in three fatalities and hundreds injured, including 17 who lost limbs. With the help of archive footage, interviews with investigators, witnesses, survivors, and occasional reenactments, it offers details about the FBI investigation into what was quickly deemed a domestic terrorist attack.
In the first episode, hours after the blasts, investigators pore over evidence. One photo and a few seconds of footage lead to a breakthrough - and an agonizing choice.