Nearly half a million years ago, the most advanced human yet roams Europe. Strong and powerful, Homo heidelbergensis are fierce hunters, use sophisticated tools and live in close-knit family groups. Over 200,000 years they become split into two populations by extremes of weather and environment and evolve separately into two very different species. In the North are the Neanderthals, whose physical power and resilience is the key to surviving in ice age Northern Europe. About 140,000 years ago, Africa is in the grip of a devastating drought, and something remarkable has happened to the descendants of heidelbergensis who live there. The combination of environment and chance has bred in them a unique ability that will change the course of human history. It will be this small band of southern survivors, perhaps numbering just a few tens of thousands, who will come to dominate the world and be known as Homo sapiens.

Garrett McNamara and his team return to Nazaré for another season of surfing. The team struggles through a number of accidents and challenges but eventually develop a set of safety procedures that enable them to surf Nazare's wave with less chance of injury or death. The struggles pay off when McNamara catches a nearly 80 foot tall wave that catapults him to international fame and makes him the holder of the world record for largest wave surfed.

Dr Janina Ramirez shows how medieval manuscripts gave power to the king and united the kingdom in an age of plague, warfare and rebellion, discovers that Edward III used the manuscripts he read as a boy to prepare him for his great victory at the battle of Crecy and reveals how a vigorous new national identity bloomed during the 100 Years War with France. In the British Library's Royal Manuscripts collection Dr Ramirez finds out that magnificent manuscripts like the Bedford Hours, taken as war booty from the French royal family, were adapted for the education of English princes. She also explores how knowledge spread through a new form of book - the encyclopaedia.

Professor Brian Cox concludes his exploration of our place in the universe by asking what next for the ape that went to space. Our future is far from certain. In Florida, Brian joins the latest efforts to protect Earth from potential catastrophic events. He joins a team of Nasa astronauts who are training for a future mission to an asteroid - should we ever discover one coming our way - under 30 feet of water in a submerged laboratory that simulates space. It is just one example of how, for our long-term survival, space exploration may well be vital. It is a view shared by Apollo 16 astronaut Charlie Duke, who tells Brian what it was like to escape the confines of the planet. It is a dream that both Nasa and now commercial companies share as they race to get humans back into deep space.
But space travel, like every leap our civilisation has ever made, requires energy. Here too, scientists are hard at work attempting to safeguard our future. At the National Ignition Facility in California, Brian witnesses the world's most successful fusion experiment in action. He believes that if their mission succeeds, our civilisation will have unlocked a way to the stars that will not destroy the planet in the process. Brian concludes by returning to the top of the world in Svalbard, where he gains access to our civilisation's greatest treasure, locked away in a vault buried deep in the permafrost.

Our wheat has changed dramatically, it doesn't even resemble what it used to look like. Not only are we seeing more wheat and gluten sensitivity, there is also a strong connection between gluten and autoimmune diseases. Tens of thousands of people are suffering with ill health and don't realise it's a result of the food choices they are making. Some assume it is part of their genetic make-up or the body changing as they get older.
People need to become educated, knowledgeable and aware. They need to start making changes to improve the health of their children and future generations.

The episode begins with Tyson describing how pattern recognition manifested in early civilization as using astronomy and astrology to predict the passing of the seasons, including how the passage of a comet was often taken as an omen. Tyson continues to explain that the origin of comets only became known in the 20th century due to the work of Jan Oort and his hypothesis of the Oort cloud. Tyson then continues to relate the collaboration between Edmond Halley and Isaac Newton in the last part of the 17th century in Cambridge. The collaboration would result in the publication of Philosophiæ Naturalis Principia Mathematica, the first major work to describe the laws of physics in mathematical terms, despite objections and claims of plagiarism from Robert Hooke and financial difficulties of the Royal Society of London. Tyson explains how this work challenged the prevailing notion that God had planned out the heavens, but would end up influencing many factors of modern life, including space flight. Tyson further describes Halley's contributions including determining Earth's distance to the sun, the motion of stars and predicting the orbit of then-unnamed Halley's Comet using Newton's laws. Tyson contrasts these scientific approaches to understanding the galaxy compared to what earlier civilizations had done, and considers this advancement as mankind's first steps into exploring the universe. The episode ends with an animation of the Milky Way and Andromeda galaxies' merging based on the principles of Newton's laws.