Carl Sagan opens the program with a description of the cosmos and the Spaceship of the Imagination. The ship journeys through the universe's hundred billion galaxies, the Local Group, the Andromeda Galaxy, the Milky Way, the Orion Nebula, our Solar System, and finally the planet Earth. Eratosthenes' successful calculation of the circumference of Earth leads to a description of the ancient Library of Alexandria. Finally, the Ages of Science are described, before pulling back to the full span of the Cosmic Calendar.

Famed astrophysicist Neil deGrasse Tyson takes a tour of the Solar System and the known universe establishing the components of Earth's "address" within the Virgo Supercluster. He then shares the story of the person who championed an expansive understanding of Earth's place in the universe by presenting Renaissance Italian Giordano Bruno's vision of the universe as a limitless expanse of space and time. He then makes an exploration into the Cosmic Calendar, which dates back to the dawn of the Big Bang (similar to the presentation from episode 1 of the original series). The episode ends with deGrasse Tyson narrating how he met his mentor Carl Sagan, who hosted the first Cosmos series.

November 4, 2029. We face a countdown to catastrophe. A giant asteroid hurtles towards Earth at 40,000 mph. It's heading straight for the eastern seaboard of the United States. The space rock could wipe out an entire city and cause widespread devastation. Can Earth survive? Now, experts confront the story of this fictional asteroid event to determine what could happen, and how it might be stopped.

Follow the four civilians as they launch into space on a three-day trip orbiting Earth and reaching an altitude higher than that of the International Space Station. The SpaceX Dragon mission, dubbed Inspiration4, is making history as the first all-civilian mission to orbit.
In the first episode, preparations begin for the mission. The commander is Jared Isaacman, a billionaire entrepreneur who purchased the flight for all four passengers, and the second crew member is a 29-year-old cancer survivor, Hayley Arceneaux.

Principles of generosity and prosperity inform the selection of the last two crew members: Christopher Sembroski, a former member of the U.S. Air Force who served in Iraq and now works as a Lockheed Martin engineer, and Sian Proctor, a professor of geosciences and two-time NASA astronaut candidate. Excitement for the flight ramps up, but anxiety lingers.

As training begins, the crew members process the physical, mental and technical demands being placed on them. The group is going to be in some intentionally uncomfortable situations and, to see how they do as a team. A climb of Mt. Rainier puts them to the test.