Follow astronaut Scott Kelly’s record-breaking 12-month mission on the International Space Station, from launch to landing, as NASA charts the effects of long-duration spaceflight. A Russian Soyuz spacecraft carried Scott Kelly of NASA and Mikhail Kornienko of Roscosmos to the space station for the longest space mission ever assigned to a NASA astronaut". The expedition provided important insights into operational and scientific areas in human research in space and on Earth. Integrated scientific investigations between NASA and Roscosmos will combine resources to improve data sharing among space medical and human research communities, as well as help inform current assessments of crew performance and health and better determine and validate countermeasures to reduce the risks associated with future exploration as NASA plans for missions around the moon, to an asteroid and eventually to Mars.