David Attenborough asks three key questions: how and why did Darwin come up with his theory of evolution? Why do we think he was right? And why is it more important now than ever before? David starts his journey in Darwin's home at Down House in Kent, where Darwin worried and puzzled over the origins of life. David goes back to his roots in Leicestershire, where he hunted for fossils as a child, and where another schoolboy unearthed a significant find in the 1950s. And he revisits Cambridge University, where both he and Darwin studied, and where many years later the DNA double helix was discovered, providing the foundations for genetics. At the end of his journey in the Natural History Museum in London, David concludes that Darwin's great insight revolutionised the way in which we see the world. We now understand why there are so many different species, and why they are distributed in the way they are. But above all, Darwin has shown us that we are not set apart from the natural world, and do not have dominion over it. We are subject to its laws and processes, as are all other animals on earth to which, indeed, we are related.

What triggered the incredible diversity of life on Earth, and how have complex life forms, including humans, evolved? Is there direction to evolution? And is human intelligence inevitable? This program focuses on evolution's 'great transformations' —among them the development of a standard four-limbed body plan, the journey from water to land, the return of marine mammals to the sea, and the emergence of humans. Driven by a combination of opportunism and a genetic 'toolkit', these astounding leaps forward define the arc of evolution. And they suggest that every living creature on earth today, and every species that has ever existed, is a variation on a grand genetic theme—a member of one, and only one, tree of life

The story begins with Tyson sitting at a campfire, and telling how the wolf changed through artificial selection, and selective breeding into the dog breeds around today. He then enters the Ship of Imagination, and explains natural selection with the process that helped to create the polar bears. Along the way he talks about DNA, genes and mutation. Next he goes to a forest and describes the Tree of life, this leads him to discussing the evolution of the eye. He then discusses extinction, by going to a monument called the Halls of Extinction, dedicated to the broken branches of the tree of life. Explaining the five great Extinction events. He then tells how some life has survived, and then focuses on the tardigrade. From there he talks about what other kinds of life might have been created on other worlds. He then goes to Saturn's moon Titan. From there he speculates about life and how it first began. He then returns to Earth and tells about abiogenesis and how life changed and evolved. The show ends with an animated sequence from the original series of life's evolution from one cell to humans.