Diseases

It is a nightmare that has stalked us for centuries: hordes of human beings transformed into mindless, cannibalistic monsters. Could this civilization-ending nightmare become reality? Scientists have discovered pathogens that turn insects into the walking dead. New strains of viruses are attacking humans every day. Mathematicians have calculated the likelihood of surviving a zombie virus outbreak: they’re not hopeful. Now neuroscientists are discovering how easy it is for us to lose conscious control of our bodies. Are we at risk of becoming puppets? If we were in the middle of a zombie apocalypse, would we even know it?

Join investigators as they untangle the cause of Alzheimer’s and race to develop a cure. Alzheimer’s disease strikes at the core of what makes us human: our capacity to think, to love, and to remember. The disease ravages the minds of over 40 million victims worldwide, and it is one of the greatest medical mysteries of our time. Join investigators as they gather clues and attempt to reconstruct the molecular chain of events that ultimately leads to dementia". Follow key researchers in the field who have helped to develop the leading theories of the disease. Along the way, meet individuals from all walks of life who will reveal what it’s like to struggle with Alzheimer’s. Among them, members of a unique Colombian family who have learned that their genetic predisposition all but guarantees early onset Alzheimer’s. Yet there may be hope. Join these courageous patients participating in clinical trials, and then go behind the scenes of the major drug trials to see how researchers target and test therapies that may slow and even prevent Alzheimer’s

Dr Chris van Tulleken, Dr Hannah Fry and Michael Mosley examine the latest research and explore some of the big questions about Covid-19 and the pandemic it has created. Michael visits the UK government's high-security laboratory Porton Down, where vaccines are being tested. He also uncovers what the experience of the 2002 SARs epidemic reveals about this one. Both were caused by coronaviruses, but certain key changes to today's virus have allowed it to infect the world, where SARs was contained.

Follow three women at risk of developing Alzheimer’s and join a groundbreaking study to try to prevent the disease, while sharing their ups and downs, anxiously watching for symptoms, and hoping they can make a difference. Barb, Sigrid, and Karen all had mothers with Alzheimer’s and witnessed first hand the devastation wrought by the disease, not only on the mind and body, but on patients’ families.

In an enthralling documentary, Dan Snow and archaeologist Raksha Dave delve into the catastrophic impact of the Black Death on Britain 700 years ago, a pandemic that extinguished around half of the population, or three million people. The duo embarks on a journey to trace the origins and merciless spread of the plague, starting from its arrival on Britain's South coast in June 1348, through the bustling trade routes that brought the disease to Melcombe Regis, Dorset. Their investigation takes them to various hotspots of the outbreak, including the Old Operating Theatre in London and Wildwood Animal Sanctuary in Kent, where they explore the role of rats in dispersing the bubonic plague. Through dramatic reconstructions and visits to places like Nottingham University's biomedical laboratories, they uncover the rapid spread and deadly impact of the plague, offering a month-by-month account of how it ravaged the country, decimating cities, towns, and villages alike.
The documentary not only showcases the horrific symptoms and desperate attempts at cures through brutal medical practices of the time but also leverages cutting-edge research to explain why the Black Death remains the deadliest pandemic in history. The personal stories of victims, from princes to paupers, are brought to light, revealing the indiscriminate nature of the disease. Dan's visit to Canterbury Cathedral and Raksha's investigation into the recent discovery of mass graves beneath a tranquil London square underline the widespread desperation and devastation. Their journey through the history of the Black Death, culminating in the discovery of its indiscriminate toll and the unveiling of mass graves in London, not only sheds light on the darkest chapters of British history but also ignites a profound understanding of the tragedy, making a compelling case for why this documentary is a must-watch for anyone interested in the profound impacts of pandemics on human society.

Of all the diseases that plague humankind, malaria has put up one of the longest, toughest fights. More than 200 million people fall ill and 600,000 die of it every year, making it among the world’s deadliest diseases. The vast majority of those fatalities are young children - an average of one child every minute. But medical science may now be at an exciting turning point.
Filmed with intimate access to key scientists on four continents, this documentary tells the inside story of the development of a new malaria vaccine that could change the very nature of the fight. It's hoped that the vaccine, dubbed R21/Matrix-M and developed by many of the same team behind the Oxford/AstraZeneca Covid-19 vaccine, will be the first to meet the World Health Organization’s target of 75 per cent efficacy.