Professor Brian Cox seeks to understand the nature of time and its role in creating both the universe and ourselves. From an extraordinary calendar built into the landscape of Peru to the beaches of Costa Rica, Brian explores the cycles of time which define our experience of life on Earth. But even the most epic cycles of life can't begin to compare to the vast expanse of cosmic time. Ultimately, Brian discovers that time is not characterised by repetition but by irreversible change. The vast universe is subject to these same laws of change. As we look out to the cosmos, we can see the story of its evolution unfold, from the death of the first stars to the birth of the youngest. This journey from birth to death will ultimately lead to the destruction not just of our planet, but also the entire universe, and with it the end of time itself. Yet without this inevitable destruction, the universe would be without what is perhaps the greatest wonder of all; the brief moment in time in which life can exist.

This fascinating journey of exploration of the connection of all things in the Universe is narrated by the legendary Sir Patrick Stewart. With the lens of science, the film reveals the mechanism linking everything in the cosmos.

The story begins with Tyson sitting at a campfire, and telling how the wolf changed through artificial selection, and selective breeding into the dog breeds around today. He then enters the Ship of Imagination, and explains natural selection with the process that helped to create the polar bears. Along the way he talks about DNA, genes and mutation. Next he goes to a forest and describes the Tree of life, this leads him to discussing the evolution of the eye. He then discusses extinction, by going to a monument called the Halls of Extinction, dedicated to the broken branches of the tree of life. Explaining the five great Extinction events. He then tells how some life has survived, and then focuses on the tardigrade. From there he talks about what other kinds of life might have been created on other worlds. He then goes to Saturn's moon Titan. From there he speculates about life and how it first began. He then returns to Earth and tells about abiogenesis and how life changed and evolved. The show ends with an animated sequence from the original series of life's evolution from one cell to humans.

Famed astrophysicist Neil deGrasse Tyson takes a tour of the Solar System and the known universe establishing the components of Earth's "address" within the Virgo Supercluster. He then shares the story of the person who championed an expansive understanding of Earth's place in the universe by presenting Renaissance Italian Giordano Bruno's vision of the universe as a limitless expanse of space and time. He then makes an exploration into the Cosmic Calendar, which dates back to the dawn of the Big Bang (similar to the presentation from episode 1 of the original series). The episode ends with deGrasse Tyson narrating how he met his mentor Carl Sagan, who hosted the first Cosmos series.

Following the wildly successful 'Cosmos: A Spacetime Odyssey,' Neil deGrasse Tyson returns as host to translate more revelations of science into a lavish transporting experience, taking audiences on a series of spiritual voyages of exploration. The show reveals previously uncharted realms, including lost worlds, worlds yet to come, and the worlds that humans may one day inhabit. Ann Druyan, original creative collaborator to Carl Sagan, whose iconic docuseries 'Cosmos' provided inspiration for this series, serves as executive producer alongside Seth MacFarlane.
Episode 1 takes viewers on a wild ride with the Ship of Imagination in an adventure spanning billions of years into the evolution of life.

This episode is centered around how science, in particular the work of Clair Patterson (voiced in animated sequences by Richard Gere[33]) in the middle of the 20th century, has been able to determine the age of the Earth. Tyson first describes how the Earth was formed from the coalescence of matter some millions of years after the formation of the Sun, and while scientists can examine the formations in rock stratum to date some geological events, these can only trace back millions of years. Instead, scientists have used the debris from meteor impacts, such as the Meteor Crater in Arizona, knowing that the material from such meteors coming from the asteroid belt would have been made at the same time as the Earth. Patterson also examined the levels of lead in the common environment and in deeper parts of the oceans and Antarctic ice, showing that lead had only been brought to the surface in recent times. He would discover that the higher levels of lead were from the use of tetraethyllead in leaded gasoline resulting in government-mandated restrictions on the use of lead.