We call them 'man’s best friend', but their story is almost as old as man himself. Our very first friend in the world, they have walked by our side for over 20,000 years, helping us to hunt for food and offering us companionship and protection. Man’s First Friend is an epic new primetime documentary event that combines natural history, science and anthropology to explore the enduring relationship between humankind and dogs, how the two species have co-evolved together, where did they come from to take such a prominent position in our lives, and how did we learn to harness their unique talents.
The film takes viewers on an extraordinary journey through some of the most remote locations in the world to answers these questions and more. It highlights what dogs are capable of: from the Pariah dog in India who protects her owner’s banana plantations from daily attacks by Black-headed Monkeys; to Kenyan Bloodhounds trained to track ivory poachers. Dogs comfort us, relieving loneliness and helping us cope with old age.

Mammals dominate the planet. They do it through having warm blood and by the care they lavish on their young. Weeks of filming in the bitter Antarctic winter reveal how a mother Weddell seal wears her teeth down keeping open a hole in the ice so she can catch fish for her pup. A powered hot air balloon produces stunning images of millions of migrating bats as they converge on fruiting trees in Zambia, and slow-motion cameras reveal how a mother rufous sengi exhausts a chasing lizard. A gyroscopically stabilised camera moves alongside migrating caribou, and a diving team swim among the planet's biggest fight as male humpback whales battle for a female.

There is no greater test for life than winter, as temperatures plummet to 70 below and winds reach 200kph. Darkness and ice extend across the polar regions and only a few remarkable survivors gamble on remaining. We join a female polar bear trekking into the Arctic mountains to give birth as the first blizzards arrive. Out on the frozen ocean, the entire world's population of spectacled eider ducks brave the winter in a giant ice hole kept open by ferocious currents. Arctic forests transform into a wonderland of frost and snow - the scene of a desperate and bloody battle between wolf and bison, but also where a remarkable alliance between raven and wolverine is made. Beneath the snow lies a magical world of winter survivors. Here tiny voles dodge the clutches of the great grey owl, but cannot escape the ultimate under-show predator - the least weasel. Midwinter and a male polar bear wanders alone across the dark, empty icescape. Below the snow, polar bear cubs begin life in an icy den while fantastical auroras light the night skies above. In Antarctica, we join male emperor penguins in their darkest hour, battling to protect precious eggs from fierce polar storms. Weddell seals escape to a hidden world of jewel-coloured corals and alien-looking creatures but frozen devastation follows as sinister ice stalactites reach down with deadly effect.

Of all the wonders of the human body, there's one more mysterious than any other. Blood: five precious litres that keep us alive. Yet how much do we really know about this sticky red substance and its mysterious, life-giving force? Michael Mosley gives up a fifth of his own blood to perform six bold experiments". From starving it of oxygen to injecting it with snake venom, Michael reveals the extraordinary abilities of blood to adapt and keep us alive. Using specialist photography, the programme reveals the beauty in a single drop. Michael even discovers how it tastes when, in a television first, he prepares a black pudding with his own blood. Down the ages, our understanding of blood has been as much myth as science, but Michael reveals there might be truth in the old vampire legends, as he meets one of the scientists behind the latest research that shows young blood might be able to reverse the ageing process - the holy grail of modern medicine.

American exchange student Amanda Knox is convicted and eventually acquitted for the 2007 death of another student in Italy. Was she a cold-blooded psychopath who brutally murdered her roommate or a naive student abroad trapped in an endless nightmare? Directors Rod Blackhurst (Tribeca Audience Award-winner Here Alone) and Brian McGinn (IDA Award-winner Chef's Table) and producer Mette Heide (Peabody Award-winner India's Daughter) explore the notorious case that made headlines around the world.

Plants' solutions to life's challenges are as ingenious and manipulative as any animal's. Innovative time-lapse photography opens up a parallel world where plants act like fly-paper, or spring-loaded traps, to catch insects. Vines develop suckers and claws to haul themselves into the rainforest canopy. Every peculiar shape proves to have a clever purpose. The dragon's blood tree is like an upturned umbrella to capture mist and shade its roots. The seed of a Bornean tree has wings so aerodynamic they inspired the design of early gliders. The barrel-shaped desert rose is full of water. The heliconia plant even enslaves a humming bird and turns it into an addict for its nectar.