Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).

The tropical Indian Ocean is home to the Spice Islands. Characterised by beautiful sandy beaches, fringing coral reefs and coastal mangrove forests, this is a vibrant nursery area for marine life, such as whale sharks, crabs, seahorses and a great variety of fish. The coastal areas are where humans have the most direct impact on the ocean's resources.

Some animals give their young the best start in life by making truly astonishing journeys. And it's not only where they go that's important but when. Left to fend for themselves until they find their footing, baby sea turtles, elephant seal pups, pumas and crabs bravely trek towards adolescence.