Dr Thomas Dixon delves into the BBC's archive to explore the troubled relationship between religion and science. From the creationists of America to the physicists of the Large Hadron Collider, he traces the expansion of scientific knowledge and asks whether there is still room for God in the modern world. He looks at what happens when new scientific discoveries start to explain events that were once seen as the workings of God, and explains how some of our most famous scientists have seen God in the grandest laws of the universe. Finally, he finds intriguing evidence from brain science which hints that belief in God is here to stay.

We live our lives pursuing happiness 'out there' as if it is a commodity. We have become slaves to our own desires and craving. Happiness isn't something that can be pursued or purchased like a cheap suit. This is Maya, illusion, the endless play of form. In the Buddhist tradition, Samsara, or the endless cycle of suffering is perpetuated by the craving of pleasure and aversion to pain. Freud referred to this as the "pleasure principle." Everything we do is an attempt to create pleasure, to gain something that we want, or to push away something that is undesirable that we don't want. Even a simple organism like the paramecium does this. It is called response to stimulus. Unlike a paramecium, humans have more choice. We are free to think, and that is the heart of the problem. It is the thinking about what we want that has gotten out of control. The dilemma of modern society is that we seek to understand the world, not in terms of archaic inner consciousness, but by quantifying and qualifying what we perceive to be the external world by using scientific means and thought. Thinking has only led to more thinking and more questions. We seek to know the innermost forces which create the world and guide its course. But we conceive of this essence as outside of ourselves, not as a living thing, intrinsic to our own nature. It was the famous psychiatrist Carl Jung who said, "one who looks outside dreams, one who looks inside awakes." It is not wrong to desire to be awake, to be happy. What is wrong is to look for happiness outside when it can only be found inside.

In the third episode of the series, Morgan Freeman examines different faiths' concepts of God, discovering how monotheism began in Egypt and Israel and allowing a neuroscientist to examine his own brain.

The U.S. authorities granted Bhagwan's visa as a religious teacher and leader. But local officials try to build a case against the Rajneeshees with the largest immigration fraud in the history of the United States. When Sheela's thirst for power, even with murder attempts, is revealed, the Bhagwan finally breaks his silence.

In the second episode of the series, Morgan Freeman looks into prophecies of violent cataclysms, and the strife of ages past, in an attempt to determine how the world will end.

The documentary deals with the future of conservation. It begins by looking at previous efforts. The 'Save The Whales' campaign, which started in the 1960s, is seen to have had a limited effect, as whaling continues and fish stocks also decline. In the 1990s, as head of the Kenya Wildlife Service, Richard Leakey took on the poachers by employing armed units. Although it was successful in saving elephants, the policy was detrimental to the Maasai people, who were forced from their land. The need for "fortress" areas is questioned, and the recently highlighted Raja Ampat coral reef in Indonesia is an example. The more tourism it generates, the greater the potential for damage — and inevitable coastal construction. Sustainable development is viewed as controversial, and one contributor perceives it to currently be a "contradiction in terms". Trophy hunting is also contentious. Those that support it argue that it generates wealth for local economies, while its opponents point to the reducing numbers of species such as the markhor. Ecotourism is shown to be beneficial, as it is in the interests of its providers to protect their environments. However, in some areas, such as the Borneo rainforests, the great diversity of species is being replaced by monocultures. The role of both religion and the media in conservation is argued to be extremely important. Contributors to the programme admit a degree of worry about the future, but also optimism.