Placebos come in all shapes and sizes, but they contain no active ingredient. They are the miracle pills that shouldn't really work at all. Now they are being shown to help treat pain, depression and even alleviate some of the symptoms of Parkinson's disease. It seems they're not acting alone. The placebo effect is intertwined with how is did the healthcare. Explores why they work, and how we could all benefit from the hidden power of the placebo.

The drug policies have remained unchanged over the last 40 years so should they be reformed in the light of new research? Recent research has analysed the link between the harmful effects of drugs relative to their current classification by law with some startling conclusions. Perhaps most startling of all is that alcohol, solvents and tobacco (all unclassified drugs) are rated more dangerous than ecstasy, 4-MTA and LSD (all class A drugs).

Over a person's lifetime they are likely to be prescribed more than 14,000 pills. Antibiotics, cholesterol lowering tablets, anti-depressants, painkillers, even tablets to extend youth and improve performance in bed. These drugs perform minor miracles day after day, but how much is really known about them? Drug discovery often owes as much to serendipity as to science, and that means much is learnt about how medicines work, or even what they do, when they're taken. By investigating some of the most popular pills people pop, Horizon asks, how much can they be trusted to do what they are supposed to?

Rocky Braat went to India as a disillusioned tourist. When he met a group of children with AIDS, he decided to stay. He never could have imagined the obstacles he would face, or the love he would find.

Ferdinand Magellan and Juan Sebastian Elcano set sail to gain control of the global spice trade, but end up becoming the first expedition to circumnavigate the earth. The yearslong voyage—along with the suffering, the violence and the loss of life and property—were all in pursuit of a shorter route to the so-called Spice Islands (now the Maluku Islands) and their much-coveted aromatics.
The film puts in perspective the 16th century—the Age of Exploration, the Age of Discovery and the Age, problematically, of Colonialism. It also was an age of heroes. As the documentary insists, the journeys undertaken by the men whose names we learned in grade school and whose exploits straddled the 1400s and 1500s—including Ponce de Leon, Vasco da Gama, Lope de Aguirre and even Columbus—were about money, sometimes trade, sometimes plunder. But just as advances in medicine have often been propelled by war, knowledge about the world has been a byproduct of profit-seeking. Likewise, heroism.

The film explores the revolutionary gene-editing tech now giving humankind the freedom to redraw the blueprint of biological life itself. We investigate not only the tremendous potential the technology holds, whether in the fight to eliminate diseases or in transforming agriculture to adapt to unprecedented climate extremes, but also probe the inherent risks involved and the potential for widespread abuse, dangers that could take our future down a very dark, dystopian path.