Series concludes with the focus shifting to the United States in the post-war years of the 1950s and beyond. Beginning with arguably the most notorious work of 20th century classical music, John Cage's 'silent' composition 4'33", it looks at how a series of maverick Americans re-invented the sound of classical music into a more simple form, bringing back harmonies and rhythms that made it increasingly popular with audiences across the world. It also examines how this music found its way into a spiritual realm, with the strain of pared-down religious composition that came to be known as 'holy minimalism'. From the Maverick concert hall in Woodstock, New York to an Orthodox cathedral in Estonia to a car park in Peckham, south London, the story is told by a stellar line-up of contributors including Philip Glass, Steve Reich, John Adams, Arvo Pärt and John Tavener.

Dr Adam Rutherford shows how decoding the genome has led us to begin to understand the very process by which our DNA makes us different; how it makes each one of us on earth unique and influences who we are and the traits we have. He reveals how, as we try and understand the relationship between who we are and our genes, we stand at the beginning of the most exciting scientific journey of all time.

The tour was designed by Willie Williams, who has worked on every U2 tour since 1982. Williams had been toying with ideas for 360-degree stadium staging for U2 for a number of years, and presented sketches of a four-legged design to the group near the end of their Vertigo Tour in 2006. The inspiration for the 'spaceship-on-four-legs' design, nicknamed 'the Claw', came from the landmark Theme Building at Los Angeles International Airport.

The 25 October 2009 concert in Pasadena, California was streamed live on U2's YouTube channel, the first time a concert was streamed live on YouTube. Over 10 million viewers streamed the concert, making it the largest streaming event in the website's history. The shoot was directed by Tom Krueger, who had previously worked with the band on the film U2 3D.

The 80s was also an age of innovators and icons, of style and substance. In this chapter, Dylan Jones celebrates some of the stars who created the timeless legacy of the 1980s. From stellar BBC archive performances from the likes of Madonna, Depeche Mode, Sade, Duran Duran, Pet Shop Boys and Tina Turner to iconic MTV-era gems from Billy Idol, Eurythmics, U2, Janet Jackson, Prince and many more.
It also features rarely seen archive television footage from the BBC vaults, including Terry Wogan interviewing Grace Jones, Bruce Springsteen on the Old Grey Whistle Test and Adam Ant performing his own stunts in a behind-the-scenes look at the making of the Prince Charming video.

To recruit actors for his rehearsals, Nathan opens an acting studio in Los Angeles, teaching 'the Fielder Method', which involves covertly observing and imitating unaware subjects. Feeling insecure about his own performance, Nathan reenacts the class with actors and a fake Nathan as the teacher while the real Nathan plays the role of Thomas, a student. Nathan makes his students immerse themselves in other people's lives while he immerses himself in Thomas's life, even living in Thomas's home.
Nathan returns to Oregon, where his 'son', Adam, is now a teenager. Nathan and Joshua, the actor playing Adam, decide that Adam should lash out due to resentment of his absentee father and develop a drug problem, a situation that mirrors Angela's own past. Adam suffers an overdose and is tended to by emergency responders played by Thomas and another Fielder Method graduate. After he runs away from home, the 15-year-old Adam reverts to a 6-year-old since Nathan plans to relive his son's earlier years.