In less than two years, Al Capone has risen from a humble bookkeeper to second-in-command of Johnny Torrio's criminal empire in Chicago. The empire is worth the modern-day equivalent of $35 million. Capone purchases a home for his family and moves them from New York to Chicago. Torrio and Capone expand their empire from Chicago's South Side to the North Side, which is controlled by Chicago's second largest gang, the Irish. Violence erupts as ruthless Irish gang leader Dean O'Banion protects his territory and bootlegging business from Torrio and Capone.

Tony Accardo have taken the reins of the criminal empire built by their mentor Al Capone. Thanks to Sam Giancana's takeover of the policy racket, the gangsters are now making millions. With so much money coming in, Accardo knows they need a place to hide it. They find their answer in a growing city where gambling is now legal: Las Vegas. However, the New York mafia is already there, led by criminal mastermind Meyer Lansky.

Some of the world's leading physicists believe they have found startling new evidence showing the existence of universes other than our own. One possibility is that the universe is so vast that an exact replica of our solar system, our planet and ourselves exists many times over. These Doppelganger Universes exist within our own Universe; in what scientist now call "The Multiverse." If proof is found it will change our lives, our minds, our planet, our science and our universe.

Lucius Vorenus, the power-hungry 'Son of Hades', controls the Aventine but practices a pointless, beastly reign of terror, coming down hard on gang captains for futilities, and nearly ruins his friendship with Pullo, whose efforts to calm things down are mistaken for disrespect and disobedience, even starts a fight once he learns the truth about Niobe; Pullio leaves Rome disgusted.
After Atia convinces Marc Antony the governorship of ghastly Macedonia after his consulate would not only be unpleasant but leave him exposed to his dangerous enemies.

Even though his wife and children are avenged by the Erastes killing, Lucius Vorenus keeps mourning for over a month till Pullo gets Marc Antony who scolds him for Caesar's death and the continuing bloody Aventine gang riots that have resulted in the gangs wanting to fill the void left by Erastes sudden demise.
Octavian is loosing patience with Mark Antony for payment of Caesar's inheritance. Meanwhile, Queen Cleopatra of Egypt arrives in Rome to pay her respects to Caesar and she also negotiates with Antony's military protection for her Pharaonic throne.

Rejected by Vorenus and Eirene and racked by guilt for the killing of Eirene's fiancé out of a jealous rage, Pullo has sunk to working as an assassin for the gangster Erastes. When Pullo gets arrested for killing one of Caesar's popular opponents, he condemns himself by refusing to name who hired him, despite Octavian's attempts to defend him.
Meanwhile, Vorenus finds his new official duties as magistrate tedious, especially when he gets caught between Caesar and the demands made by veterans' spokesman Mascias.