A Winning Design clarifies what makes a mammal different from reptiles and birds. No, it isn't egg-laying: both the platypus and the echidna are egg-laying mammals; it's their ability to adapt. And it's this adaptability that becomes the crux of the remainder of the series. From the tiniest bat to the massive blue whale, all mammals share the ability to nurture their young on milk and regulate their own temperatures.

Leaving Everest base camp to take the high road to Lhasa to see what the Chinese have done to Tibet. He sees that religion is once again tolerated, while the old Tibetan centre of the city is being replaced with modern Chinese shopping malls and nightclubs. Following the pilgrims to the holy Namtso Lake, he gets warm in a hot spring before learning how to milk a yak with a nomad family.

Our galaxy is one of hundreds of billions in the universe. View of universe through the Hubble telescope and go back almost all the way to the Big Bang.

Beginning with the origins of the universe in the Big Bang, Sagan describes the formation of different types of galaxies and anomalies such as galactic collisions and quasars. The episodes moves further into ideas about the structure of the Universe, such as different dimensions (in the imaginary Flatland and four-dimensional hypercubes), an infinite vs. a finite universe, and the idea of an oscillating Universe (similar to that in Hindu cosmology). The search into other ideas such as dark matter and the multiverse is shown, using tools such as the Very Large Array in New Mexico. Cosmos Update shows new information about the odd, irregular surfaces of galaxies and the Milky Way perhaps being a barred spiral galaxy

Questions are raised about the search for intelligent life beyond the Earth, with UFOs and other close encounters refuted in favor of communications through SETI and radio telescope such as the Arecibo Observatory. The probability of technically advanced civilizations existing elsewhere in the Milky Way is interpreted using the Drake equation and a future hypothetical Encyclopedia Galactica is discussed as a repository of information about other worlds in the galaxy. The Cosmos Update notes that there have been fewer sightings of UFOs and more stories of abductions, while mentioning the META scanning the skies for signals.

Across the universe, galaxies are going dark, and scientists don't know why the stars are losing their shine. Something is slowly drawing the curtains closed on the universe. Our milky way is under threat. Astronomers race against time to uncover the truth behind how galaxies are born and how they die before all of the lights go out.