Over a person's lifetime they are likely to be prescribed more than 14,000 pills. Antibiotics, cholesterol lowering tablets, anti-depressants, painkillers, even tablets to extend youth and improve performance in bed. These drugs perform minor miracles day after day, but how much is really known about them? Drug discovery often owes as much to serendipity as to science, and that means much is learnt about how medicines work, or even what they do, when they're taken. By investigating some of the most popular pills people pop, Horizon asks, how much can they be trusted to do what they are supposed to?

Ferdinand Magellan and Juan Sebastian Elcano set sail to gain control of the global spice trade, but end up becoming the first expedition to circumnavigate the earth. The yearslong voyage—along with the suffering, the violence and the loss of life and property—were all in pursuit of a shorter route to the so-called Spice Islands (now the Maluku Islands) and their much-coveted aromatics.
The film puts in perspective the 16th century—the Age of Exploration, the Age of Discovery and the Age, problematically, of Colonialism. It also was an age of heroes. As the documentary insists, the journeys undertaken by the men whose names we learned in grade school and whose exploits straddled the 1400s and 1500s—including Ponce de Leon, Vasco da Gama, Lope de Aguirre and even Columbus—were about money, sometimes trade, sometimes plunder. But just as advances in medicine have often been propelled by war, knowledge about the world has been a byproduct of profit-seeking. Likewise, heroism.

We are in the grip of an allergy epidemic. 50 years ago one in 30 were affected, but in Britain today it is closer to one in three. Why this should be is one of modern medicine's greatest puzzles. In search of answers, Horizon travels round the globe, from the remotest inhabited island to the polluted centres of California and the UK. We meet sufferers and the scientists who have dedicated their lives trying to answer the mystery of why we are becoming allergic to our world.

Just outside Paris, inside a hi-tech vault, and encased in three vacuum-sealed bell jars, rests a small metallic cylinder about the diameter of a golf ball. It may not look like much, but it is one of the most important objects on the planet. It affects nearly every aspect of our lives including the food we eat, the cars we drive, even the medicines we take. It is the Kilogramme, the base unit of mass in the International System of Units. Yet over time, its mass has mysteriously eroded by the weight of an eyelash. A change that, unbeknownst to most, unleashed a crisis with potentially dire consequences.
The film follows the ensuing high-stakes, two-year race to redefine the weight of the world, and tells the story of one of the most important objects on the planet.

The attempt to send and land astronauts on Mars risks billions of dollars and the lives of those brave enough to attempt it. Is the possible benefit really worth the risk? And is it really achievable? Guiding us through this ethical and scientific minefield is Dr Kevin Fong. Kevin's diverse background in astrophysics, aeronautics and medicine makes him uniquely placed to understand the technical and human challenges of this perilous journey. He leads us through the journey to Mars stage by stage. For Kevin, not only is this the toughest journey we will ever attempt, it is one that he feels we ultimately must make if we are to survive as a species.

Richard Dawkins examines the growing suspicion the public has for science-based medicine, despite its track record of successes like the germ theory of disease, vaccines, antibiotics and increased lifespan. He notes a fifth of British children are currently not immunised against measles, mumps and rubella, attributing it to fears arising from a highly controversial report linking the vaccine with autism. Dawkins criticizes the growing field of alternative medicine which does not pass the same objective and statistical rigour as scientifically derived treatments using controlled double-blind studies. Without verifiable evidence, alternative therapies must rely on biased anecdotes and word of mouth to perpetuate. Dawkins observes these treatments have fanciful rationales and rituals behind them, with many alternative treatments employing pseudoscientific jargon such as "energy", "vibration" or "quantum theory" to give themselves greater credence to patients.