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Is mankind alone, or are there aliens out there, either waiting to be discovered, or on their way to find Earth? Professor Brian Cox spends this episode asking such questions, and what he discovers may raise a few eyebrows. He begins by exploring the human race's efforts to find neighbours in outer space, including the launch of two golden discs containing a greeting from Earth in the 1970s; they are still travelling and are now the most distant man-made objects from the planet. Brian also meets members of the Search for Extra-Terrestrial Intelligence, who have been monitoring radio signals for 50 years without success, before discussing the ingredients needed to make an intelligent civilisation with astrophysicist Dr Frank Drake.

Brian Cox looks at our attempts to answer one of the most profound questions we can ask – are we alone in the universe? With scientists sending space probes to the furthest reaches of our solar system and beyond, the scientific search for alien life has begun. Inspired by a childhood love of science fiction, Brian still hopes to hear from ET. In this film, he explains why this search deserves to be taken seriously, and he explores the chances of it happening.