The story begins with Tyson sitting at a campfire, and telling how the wolf changed through artificial selection, and selective breeding into the dog breeds around today. He then enters the Ship of Imagination, and explains natural selection with the process that helped to create the polar bears. Along the way he talks about DNA, genes and mutation. Next he goes to a forest and describes the Tree of life, this leads him to discussing the evolution of the eye. He then discusses extinction, by going to a monument called the Halls of Extinction, dedicated to the broken branches of the tree of life. Explaining the five great Extinction events. He then tells how some life has survived, and then focuses on the tardigrade. From there he talks about what other kinds of life might have been created on other worlds. He then goes to Saturn's moon Titan. From there he speculates about life and how it first began. He then returns to Earth and tells about abiogenesis and how life changed and evolved. The show ends with an animated sequence from the original series of life's evolution from one cell to humans.

This episode explores the palaeogeography of Earth over millions of years, and its impact on the development of life on the planet. Tyson starts by explaining that the lignin-rich trees evolved in the Carboniferous era about 300 million ago, then explains on the nature of plate tectonics that would shape the landmasses of the world and the asteroid impact that initiated the Cretaceous–Paleogene extinction event, leaving small mammals as the dominate species on earth. Earth's landmasses are expected to change in the future and postulates what may be the next great extinction event.

Fly across iridescent tropical reefs, brush through a cloud of a million jellyfish, visit an alien world where the closer you look, the more you see, where the tiniest creatures support the greatest predators... We think of reefs as exotic, distant places with little or no connection to our everyday world. Yet every reef is a living city beneath the sea with a parallel existence to ours, distant yet undeniably connected. Reefs are hotspots of biodiversity as vital to life on earth as the rain-forests. They have been shaping our shorelines, literally forming islands and mountains, for millions of years. The fossil record shows that given time they have recovered from all of earth's major extinction events. Even reefs pulverised by atomic blasts at Bikini Atoll have regenerated. Yet within our lifetime reefs have come to face their greatest threat...

Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).

A new force threatens our perfect planet. In the past, five mass extinction events were caused by cataclysmic volcanic eruptions. It was not the lava or ash that wiped out life, but an invisible gas released by volcanoes: carbon dioxide. Almost every part of modern life depends on energy created by burning fossil fuels, and this produces CO2 in huge amounts. Humans are changing our planet so rapidly, it’s affecting earth’s life support systems: our weather, our oceans and the living world. The greatest change to be made is in how we create energy, and the planet is brimming with natural power that can help us do just that. It’s these forces of nature - the wind, the sun, waves and geothermal energy - that hold the key to our future.
Through compelling animal-led stories and expert interviews, we discover how CO2 is destabilising our planet. We meet rescued orphaned elephants in Kenya, victims of ever worsening droughts, and join ocean patrols off the coast of Gabon fighting to save endangered sharks. In the Amazon, we witness wildlife teams saving animals in the shrinking forests, and in San Diego we enter a cryogenic zoo preserving the DNA of endangered species before they become extinct.

Beneath Yellowstone National Park, lies the biggest volcano on Earth. An eruption in the past was so big it plunged the earth into a volcanic winter that lasted years. A super-eruption would be more than millions of Hiroshima bombs going off all at once. It would be even worse than an asteroid impact: Entire cities lost beneath ash, people and animals crushed alive, power networks destroyed, sun dimmed across the globe, harvests failed, widespread famine. Could this nightmare really happen? We will use the latest scientific data to uncover the danger beneath us, as we see our planet like never before.