In the fifth episode Neil deGrasse Tyson explores questions that have baffled scientists for centuries. Can we know the universe? Are our brains capable of comprehending the cosmos in all of its complexity and splendor?. We don't yet know the answers because our brain remains almost as much of a mystery to that questions as the universe itself. An abandoned orphan's dream opened the way to understanding the architecture of thought.

The nervous system is fundamentally electric. When we move our arm, it moves because a electric signal has been sent to the muscle that controls it. Now, because the brain is electric, we could also use electricity to record what the brain is doing or bypass it entirely, and control a body. That means that we could restore movement to people who are paralyzed, feel through an artificial hand as if it was our own, and even read people's minds.
Michael Stevens explores how electricity can be used to move cockroaches, control other peoples' limbs and even read peoples' thoughts.

Autistic minds provide windows into how we all think, feel, and behave. A complete brain science should be able to account for all kinds of minds and brains. As long as some minds remain a mystery, so too will all minds.
Michael Stevens travels to London to meet a blind, autistic savant with astonishing musical abilities, and volunteers to have his brain's function temporarily disrupted at UCLA's Neuromodulation Lab.

When it comes to illusions, optical illusions get all the attention. But the whole body you have can be fooled and can fool the brain. What is touch? Is it real, or is it just in our heads? Michael Stevens decides to find out.

Everyone always wants to be able to choose - but who really makes these choices? And do we really want to have more choices? Michael Stevens finds out as he explores decision-making.

Your brain is like a hungry sponge. It's constantly absorbing information. It thrives when stimulated. Between smartphones and books, and movies, and friends and family, thousands of sensations are constantly going into our heads. But what if it all got cut off?. Imagine being confined to a 10-by-10-foot room in complete isolation. No timekeeping devices, no phones, no books, nothing to write on, no windows. Psychologists say that fewer than three days in a room like this can lead to brain damage. I will be staying in this room for three days.
Michael explores the effects of isolation on the human mind by subjecting himself to a very interesting experiment.