Is mankind alone, or are there aliens out there, either waiting to be discovered, or on their way to find Earth? Professor Brian Cox spends this episode asking such questions, and what he discovers may raise a few eyebrows. He begins by exploring the human race's efforts to find neighbours in outer space, including the launch of two golden discs containing a greeting from Earth in the 1970s; they are still travelling and are now the most distant man-made objects from the planet. Brian also meets members of the Search for Extra-Terrestrial Intelligence, who have been monitoring radio signals for 50 years without success, before discussing the ingredients needed to make an intelligent civilisation with astrophysicist Dr Frank Drake.

Odds are excellent that extraterrestrial life exists. So why haven’t we found aliens out in the galaxy? Are we looking in the wrong places? New research shows we should look closer to home, even inside our bodies. It turns out that a lot of our DNA is from a mysterious, nonhuman source. Theoretically, alien microbial life can make the journey to Earth from distant worlds, and scientists are finding some unearthly microbes in our upper atmosphere. Could it be from outer space? Could we be part alien? It’s even possible alien life is already here as digital life forms, hiding inside our technology.