The story begins with Tyson sitting at a campfire, and telling how the wolf changed through artificial selection, and selective breeding into the dog breeds around today. He then enters the Ship of Imagination, and explains natural selection with the process that helped to create the polar bears. Along the way he talks about DNA, genes and mutation. Next he goes to a forest and describes the Tree of life, this leads him to discussing the evolution of the eye. He then discusses extinction, by going to a monument called the Halls of Extinction, dedicated to the broken branches of the tree of life. Explaining the five great Extinction events. He then tells how some life has survived, and then focuses on the tardigrade. From there he talks about what other kinds of life might have been created on other worlds. He then goes to Saturn's moon Titan. From there he speculates about life and how it first began. He then returns to Earth and tells about abiogenesis and how life changed and evolved. The show ends with an animated sequence from the original series of life's evolution from one cell to humans.

Beginning with the separation of the fuzzy thinking and pious fraud of astrology from the careful observations of astronomy, Sagan follows the development of astronomical observation. Beginning with constellations and ceremonial calendars (such as those of the Anasazi), the story moves to the debate between Earth and Sun-centered models: Ptolemy and the geocentric worldview, Copernicus' theory, the data-gathering of Tycho Brahe, and the achievements of Johannes Kepler (Kepler's laws of planetary motion and the first science-fiction novel).

Brian asks how, from a lifeless cosmos, it is possible that a planet can produce the more than eight million species we know of.

We think of comets as beautiful glowing balls of light streaking across our skies with their long sweeping tails, yet comets are so much more than just a cosmic firework display. Comets have a uniquely important place in modern science. As time machines from the early universe, they could hold the key to unlock the secrets of the cosmos. Comets could even be the origin of life itself. We follow the incredible odyssey of a comet as it sails through the solar system, watching it's every move as it evolves from a dormant chunk of ice and rock into a tumbling, violently active nucleus engulfed in a gaseous haze. What we learn is a revelation; comets are even more mysterious and fascinating than we had ever imagined.

Is God worshipped in other worlds, across the cosmos? How might alien deities differ from our own? The answer may lie buried on Earth. Animal behaviorists are testing elephants and finding them capable of having spiritual thoughts. Artificial intelligence researchers are building enlightened robots that contemplate the divine. Meanwhile, cosmologists are looking for universal equations that could replace God. Have advanced aliens discovered everything there is to know about the universe? Or are they looking to a higher power for answers?

Discover the Eras of the Universe and the answer to this big question: When Will Time End? Once the notion that the universe started with a rapid inflation nicknamed the Big Bang became accepted by the majority of scientists, many possible fates are predicted by rival scientific hypotheses, including futures of both finite and infinite duration. The ultimate fate of the universe is dependent on the shape of the universe and what role Dark energy will play as the universe ages.