Join investigators as they untangle the cause of Alzheimer’s and race to develop a cure. Alzheimer’s disease strikes at the core of what makes us human: our capacity to think, to love, and to remember. The disease ravages the minds of over 40 million victims worldwide, and it is one of the greatest medical mysteries of our time. Join investigators as they gather clues and attempt to reconstruct the molecular chain of events that ultimately leads to dementia". Follow key researchers in the field who have helped to develop the leading theories of the disease. Along the way, meet individuals from all walks of life who will reveal what it’s like to struggle with Alzheimer’s. Among them, members of a unique Colombian family who have learned that their genetic predisposition all but guarantees early onset Alzheimer’s. Yet there may be hope. Join these courageous patients participating in clinical trials, and then go behind the scenes of the major drug trials to see how researchers target and test therapies that may slow and even prevent Alzheimer’s

Evolution tells us that all life exists for only one purpose: to reproduce. But is that all there is? How could such a simple imperative lead us to create great art and civilizations? A new theory suggests that instead of passing on genes, our ultimate purpose is to process and pass on information. We are the universe figuring itself out. Scientists dig deep into DNA, chemistry, technology and engineering to find the meaning of life. One thing is certain: living is easier if you find a reason for living.

Follow astronaut Scott Kelly’s record-breaking 12-month mission on the International Space Station, from launch to landing, as NASA charts the effects of long-duration spaceflight. A Russian Soyuz spacecraft carried Scott Kelly of NASA and Mikhail Kornienko of Roscosmos to the space station for the longest space mission ever assigned to a NASA astronaut". The expedition provided important insights into operational and scientific areas in human research in space and on Earth. Integrated scientific investigations between NASA and Roscosmos will combine resources to improve data sharing among space medical and human research communities, as well as help inform current assessments of crew performance and health and better determine and validate countermeasures to reduce the risks associated with future exploration as NASA plans for missions around the moon, to an asteroid and eventually to Mars.

The drug policies have remained unchanged over the last 40 years so should they be reformed in the light of new research? Recent research has analysed the link between the harmful effects of drugs relative to their current classification by law with some startling conclusions. Perhaps most startling of all is that alcohol, solvents and tobacco (all unclassified drugs) are rated more dangerous than ecstasy, 4-MTA and LSD (all class A drugs).

Scientific advancements are challenging the concept of what it means to be human. Technology embedded in our bodies is fairly common: artificial limbs, pacemakers. But new research is taking us beyond replacement parts and into a new realm that is changing the nature of the human body and the human mind. Will the fusion of biology and technology change how we think, how we feel, how we experience the world?

Dr Alice Roberts asks one of the great questions about our species: are we still evolving? There's no doubt that we're a product of millions of years of evolution. But thanks to modern technology and medicine, did we escape Darwin's law of the survival of the fittest? Alice follows a trail of clues from ancient human bones to studies of remarkable people living in the most inhospitable parts of the planet and the frontiers of genetic research, to discover if we are still evolving - and where we might be heading.