We now know that the brain - the organ that more than any other makes us human - is one of the wonders of the universe, and yet until the 17th century it was barely studied. The twin sciences of brain anatomy and psychology have offered different visions of who we are. Now these sciences are coming together and in the process have revealed some surprising and uncomfortable truths about what really shapes our thoughts, feelings and desires. And the search to understand how our brains work has also revealed that we are all - whether we realise it or not - carrying out science from the moment we are born.

Of all the wonders of the human body, there's one more mysterious than any other. Blood: five precious litres that keep us alive. Yet how much do we really know about this sticky red substance and its mysterious, life-giving force? Michael Mosley gives up a fifth of his own blood to perform six bold experiments". From starving it of oxygen to injecting it with snake venom, Michael reveals the extraordinary abilities of blood to adapt and keep us alive. Using specialist photography, the programme reveals the beauty in a single drop. Michael even discovers how it tastes when, in a television first, he prepares a black pudding with his own blood. Down the ages, our understanding of blood has been as much myth as science, but Michael reveals there might be truth in the old vampire legends, as he meets one of the scientists behind the latest research that shows young blood might be able to reverse the ageing process - the holy grail of modern medicine.

Professor Jim Al-Khalili discovers the intriguing story of how we discovered the rules that drive the universe. Energy is vital to us all, but what exactly is energy? In attempting to answer this question Jim investigates a strange set of laws that link together everything from engines to humans to stars. It turns out that energy, so critical to daily existence, actually helps us make sense of the entire universe.

Author Henry Hitchings explores the lives and works of Britain's radical and pioneering 18th-century novelists who, in just 80 years, established all the literary genres we recognise today. It was a golden age of creativity led by Daniel Defoe, Jonathan Swift, Henry Fielding, Laurence Sterne, Fanny Burney and William Godwin, amongst others. Robinson Crusoe, Gulliver's Travels, Tom Jones and Tristram Shandy are novels that still sparkle with audacity and innovation. On his journey through 18th-century fiction, Hitchings reveals how the novel was more than mere entertainment, it was also a subversive hand-grenade that would change British society for the better. He travels from the homes of Britain's great and good to its lowliest prisons, meeting contemporary writers like Martin Amis, Will Self, Tom McCarthy and Jenny Uglow on the way.

Professor Robert Bartlett explores the impact of the Normans on southern Europe and the Middle East. The Normans spread south in the 11th century, winning control of southern Italy and the island of Sicily. There they created their most prosperous kingdom, where Christianity and Islam co-existed in relative harmony and mutual tolerance. It became a great centre of medieval culture and learning. But events in the Middle East provoked the more aggressive side of the Norman character. In 1095, the Normans enthusiastically answered the Pope's call for holy war against Islam and joined the first crusade. They lay siege to Jerusalem and eventually helped win back the holy city from the muslims. This bloody conquest left a deep rift between Christianity and Islam which is still being felt to this day.

Even after thousands of years of ice crushing the northern hemisphere and temperatures of 20 degrees lower than those of today, many of the great giants of the ice age still walked the earth. It was only when the world had warmed up again that mammoths, woolly rhinos, sabre-toothed cats, giant ground sloths and glyptodonts finally became extinct. Professor Alice Roberts sets off on her last voyage back to the Ice Age to discover why.