For centuries scientists have been attempting to come up with an elixir of youth. Now remarkable discoveries are suggesting that ageing is something flexible that can ultimately be manipulated. The scientists are attempting to piece together why we age and more vitally for all of us, what we can do to prevent it. But which theory will prevail? Does the real key to controlling how we age lie with a five-year-old boy with an extraordinary ageing disease or with a self-experimenting Harvard professor? Could one of these breakthroughs really see our lives extend past 120 years?

Professor Richard Fortey delves into the fascinating and normally-hidden kingdom of fungi. From their spectacular birth, through their secretive underground life to their final explosive death, Richard reveals a remarkable world that few of us understand or even realise exists - yet all life on Earth depends on it. In a specially-built mushroom lab, with the help of mycologist Dr Patrick Hickey and some state-of-the-art technology, Richard brings to life the secret world of mushrooms as never seen before and reveals the spectacular abilities of fungi to break down waste and sustain new plant life, keeping our planet alive. Beyond the lab, Richard travels across Britain and beyond to show us the biggest, fastest and most deadly organisms on the planet - all of them fungi. He reveals their almost magical powers that have world-changing potential - opening up new frontiers in science, medicine and technology.

Richard Dawkins examines the growing suspicion the public has for science-based medicine, despite its track record of successes like the germ theory of disease, vaccines, antibiotics and increased lifespan. He notes a fifth of British children are currently not immunised against measles, mumps and rubella, attributing it to fears arising from a highly controversial report linking the vaccine with autism. Dawkins criticizes the growing field of alternative medicine which does not pass the same objective and statistical rigour as scientifically derived treatments using controlled double-blind studies. Without verifiable evidence, alternative therapies must rely on biased anecdotes and word of mouth to perpetuate. Dawkins observes these treatments have fanciful rationales and rituals behind them, with many alternative treatments employing pseudoscientific jargon such as "energy", "vibration" or "quantum theory" to give themselves greater credence to patients.

The drug policies have remained unchanged over the last 40 years so should they be reformed in the light of new research? Recent research has analysed the link between the harmful effects of drugs relative to their current classification by law with some startling conclusions. Perhaps most startling of all is that alcohol, solvents and tobacco (all unclassified drugs) are rated more dangerous than ecstasy, 4-MTA and LSD (all class A drugs).

Michael Mosley has set himself a truly ambitious goal: he wants to live longer, stay younger and lose weight in the bargain. And he wants to make as few changes to his life as possible along the way. He discovers the powerful new science behind the ancient idea of fasting, and he thinks he's found a way of doing it that still allows him to enjoy his food. Michael tests out the science of fasting on himself - with life-changing results.

Dr Alice Roberts asks one of the great questions about our species: are we still evolving? There's no doubt that we're a product of millions of years of evolution. But thanks to modern technology and medicine, did we escape Darwin's law of the survival of the fittest? Alice follows a trail of clues from ancient human bones to studies of remarkable people living in the most inhospitable parts of the planet and the frontiers of genetic research, to discover if we are still evolving - and where we might be heading.