Rembrandt's success in his early years was as a portrait painter to the rich denizens of Amsterdam at a time when the city was being transformed from a small nondescript port into the economic capital of the world. His historical and religious paintings also gave him wide acclaim. Despite being known as a portrait painter Rembrandt used his talent to push the boundaries of painting. This direction made him unpopular in the later years of his career as he shifted from being the talk of the town to becoming adrift in the Amsterdam art scene and criticised by his peers.

This episode explores what can give brains a boost. In America, Angela tries out a new treatment that's proven to help memory and concentration. In Japan, a remarkable 100-year-old reveals the colourful foods that keep minds more active. Plus Chris discovers the best exercise we can do for our brains. At the cutting-edge of science, discover how injections of young people's blood may help beat dementia.

This episode covers the nature of how life may have developed on Earth and the possibility of life on other planets. Tyson begins by explaining how the human development of writing systems enabled the transfer of information through generations, describing how Princess Enheduanna ca. 2280 BCE would be one of the first to sign her name to her works, and how Gilgamesh collected stories, including that of Utnapishtim documenting a great flood comparable to the story of Noah's Ark. Tyson explains how DNA similarly records information to propagate life, and postulates theories of how DNA originated on Earth, including evolution from a shallow tide pool, or from the ejecta of meteor collisions from other planets. In the latter case, Tyson explains how comparing the composition of the Nakhla meteorite in 1911 to results collected by the Viking program demonstrated that material from Mars could transit to Earth, and the ability of some microbes to survive the harsh conditions of space. With the motions of solar systems through the galaxy over billions of years, life could conceivably propagate from planet to planet in the same manner. Tyson then moves on to consider if life on other planets could exist. He explains how Project Diana performed in the 1960s showed that radio waves are able to travel in space, and that all of humanity's broadcast signals continue to radiate into space from our planet. Tyson notes that projects have since looked for similar signals potentially emanating from other solar systems. Tyson then explains that the development and lifespan of extraterrestrial civilizations must be considered for such detection to be realized. He notes that civilizations can be wiped out by cosmic events like supernovae, natural disasters such as the Toba disaster, or even self-destruct through war or other means, making probability estimates difficult. Tyson describes how elliptical galaxies, in which some of the oldest red dwarf stars exist, would offer the best chance of finding established civilizations. Tyson concludes that human intelligence properly applied should allow our species to avoid such disasters and enable us to migrate beyond the Earth before the Sun's eventual transformation into a red giant.

The terrorist group Boko Haram is responsible for thousands of deaths in Nigeria. Now, the government is determined to drive these militants from the country. But is the hunt for insurgents causing as much harm as it's preventing? Former Navy SEAL and new VICE correspondent Kaj Larsen travels to Nigeria to see what this cat-and-mouse game means for the people caught in the middle of the fight. 'Unnatural Selection': For centuries, scientists have been working to change the genetic traits of plants and animals. Now, the new gene-editing method CRISPR has made that process astonishingly simple - so simple it could easily be used on humans. Isobel Yeung reports from Brazil, Scotland, China and the U.S. on the technological advances that could reshape evolution as we know it.

While scientists have previously theorised about a “Big Crunch” where the universe retracts back to its original size, the discovery of Dark Matter and Dark Energy has placed that hypothesis on the backburner. Some astronomers now believe that if Dark Matter offsets Dark Energy then as the universe slowly expands, stars will gradually fade, running out of fuel and leading to a dark, cold and lifeless universe. Others hypothesise a much more violent end where Dark Energy continues to expand the universe at a greater and greater speed. Stronger than gravity, Dark Energy would pull apart everything down to the fundamental particles – the universe’s very fibres. While the universe’s end may be 50 billion years away, great leaps in science will continue to alter how we believe the universe was formed – and how it will end.

The Arctic and Antarctic experience the most extreme seasons on Earth. Time-lapse cameras watch a colony of emperor penguins, transforming them into a single organism. The film reveals new science about the dynamics of emperor penguin behaviour. In the north, unique aerial images show a polar bear swimming more than 100km. Diving for up to two minutes at a time. The exhausted polar bear later attacks a herd of walrus in a true clash of the Titans.