Mehmed II sends his elite troops into the teeth of Emperor Constantine's defenses along the city's ancient stone walls. The defenders, led by Italian soldier-of-fortune Giovanni Giustiniani, repel every attack. Mehmed's men dig underground tunnels in an attempt to shatter city walls. The tides turn against the Ottomans when a naval blockade founders.

April 1453. Sultan Mehmed II unleashes an artillery attack on Constantinople unlike any the world has ever known. It's the largest concentration of cannons that the world had seen in one place. The monumental task of keeping the Ottomans out of Constantinople falls on the shoulders of Genoese soldier of fortune Giovanni Giustiniani. He and his men must defend 14 miles of city walls. Mehmed launches his ambitious plans to break through the walls of Constantinople, but Giustiniani's mercenaries manage to forestall the attacks.

Ottoman Sultan Mehmed II wages an epic campaign to take the Byzantine capital of Constantinople. Twenty-three armies have tried to take the legendary city and all have failed. Out of the carnage, one ruler will emerge victorious and shapes the course of history for centuries. For one empire to rise, another must fall.
The Ottomans, former Anatolian warlords and nomads who've built a burgeoning empire are the biggest threat to the Romans' 1100-year reign. The death of Ottoman Sultan Murad II in 1451 unleashes a chain of events that will soon bring the Ottomans and Romans to the brink of war. After claiming the Ottoman throne, Mehmed II sends an unmistakable signal to Byzantine emperor Constantine XI.

At 11 o'clock on New Year's Eve of the Cosmic Calendar, Homo erectus stood up for the first time, freeing its hands and earning the species its name. They began to move around, to explore, daring to risk everything to get to unknown places. Our Neanderthal relatives lived much as we did and did many of the things we consider to be 'human.' More restless than their cousins the Neanderthals and Denisovans, our Homo sapiens ancestors crossed seas and unforgiving landscapes, changing the land, ocean and atmosphere, leading to mass extinction. The scientific community gave our age a new name, 'Anthropocene.'
Since the first civilizations we've wondered if there's something about human nature that contains the seeds of our destruction. Syukuro Manabe was born in rural Japan and took an intense interest in Earth's average global temperature. In the 1960's, he would assemble the evidence he needed to predict the increase of Earth's temperature due to greenhouse gases until it becomes an uninhabitable and toxic environment, leading to our extinction. 'This doesn't have to be,' says Neil deGrasse Tyson, 'it's not too late. There's another hallway, another future we can still have; we'll find a way.'

A child lies on the rug of a tenement dreaming of interstellar adventures. At the dawn of the space age, a young Carl Sagan’s career is forged in the clash of his mentors, two scientific titans. Sagan goes on realize his childhood dreams, to carry their research forward and communicate its significance to the whole world.

The fourth episode sees host Neil deGrasse Tyson exploring our eternal quest to end hunger and honoring Nikolai Ivanovic Vavilov, pioneer of modern plant breeding, who risked his life for a discovery that would change the history of science. Vavilov's story is marked by both the tenacity and creativity and is particularly tragic. Interwoven into Vavilov's somber narrative are warnings and treatments of science and its ethical implications, especially when science itself comes under attack from political forces.