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Adam Rutherford meets a new creature created by American scientists, the spider-goat. It is part goat, part spider, and its milk can be used to create artificial spider's web. It is part of a new field of research, synthetic biology, with a radical aim: to break down nature into spare parts so that we can rebuild it however we please. This technology is already being used to make bio-diesel to power cars. Other researchers are looking at how we might, one day, control human emotions by sending 'biological machines' into our brains.

Does life exist on other planets? Astrobiology is a visionary new science that searches for life in space by combining the disciplines of astronomy, biology and geology. How did life evolve on Earth? What will life look like on other planets? These and other pertinent questions will be answered by a diverse group of scientists. Viewers will visit the Pilbara region of West Australia where the oldest evidence of life on Earth has been discovered. Travel to the moons of Jupiter and Saturn to test a theory that life could exist in the clouds of Venus. Finally, watch as experiments are done to see if life exists on exoplanets, earth-like planets beyond our solar system.

Around 30% of the land's surface is desert, the most varied of our ecosystems despite the lack of rain. Unravel the secrets of desert survival and experience the ephemeral nature of this dynamic environment. Watch Saharan sandstorms nearly a mile high and desert rivers that run for a single day. In the Gobi Desert, rare Bactrian camels get moisture from the snow. In the Atacama, guanacos survive by licking dew off cactus spines. In the USA, the brief blooming of Death Valley triggers a plague of locusts 65km wide and 160km long. A unique aerial voyage over the Namibian desert reveals elephants on a long trek for food and desert lions searching for wandering oryx.

Is mankind alone, or are there aliens out there, either waiting to be discovered, or on their way to find Earth? Professor Brian Cox spends this episode asking such questions, and what he discovers may raise a few eyebrows. He begins by exploring the human race's efforts to find neighbours in outer space, including the launch of two golden discs containing a greeting from Earth in the 1970s; they are still travelling and are now the most distant man-made objects from the planet. Brian also meets members of the Search for Extra-Terrestrial Intelligence, who have been monitoring radio signals for 50 years without success, before discussing the ingredients needed to make an intelligent civilisation with astrophysicist Dr Frank Drake.

Francisco de Orellana failed to find El Dorado, but discovered the Amazon. Early in 1541, a rumor swept Quito that beyond the mountains, there lay a land richer than Mexico, or even Peru - a land of gold. The ruler of this land was so rich that he covered himself with gold dust every day and washed it off every evening. He was "the golden man", El Dorado. They had tree goals: to find La Canela, the land of cinnamon: to assess new lands for colonization; and to find El Dorado. On march 1541, They marched eastwards with more that 200 Spanish troops and thousands of native servants.

A journey through the cosmos in search of alien life. We seek out planets around distand stars and dive into the oceans of other worlds - seeking an answer to the question: is there anybody out there?