Around the world, a new generation of astronomers are hunting for the most mysterious objects in the universe. Young stars, black holes, even other forms of life. They have created a dazzling new set of super-telescopes that promise to rewrite the story of the heavens. This film follows the men and women who are pushing the limits of science and engineering in some of the most extreme environments on earth. But most strikingly of all, no-one really knows what they will find out there.

Following the Yangtze along Tiger Leaping Gorge into Yunnan in China, Palin reaches the easternmost end of the Himalayas. He gets a medical check-up before exploring medieval Lijiang with the director of the local orchestra. Heading over Myanmar to Nagaland in India he rides the steam train to Tipong Coalmine. In Assam he rides an elephant and then stays in a strange monastery.

The Russian Arctic is one of the world’s most extreme habitats, yet it is a haven for polar bears, lemmings, arctic foxes and walruses. In late August, massive muskoxen bulls gather together to compete for mating dominance. Each bull can weigh 400 kilogram’s and charge at a speed of 40 kilometres an hour; a head-to-head impact can be heard more than a kilometre away

Oil theft has become big business in Nigeria. Travel to this Africa's oil-producing region to meet with oil thieves, and follows one farmer's attempt to sue a foreign oil company for poisoning his family's land. The lethal combination of gangs and guns has turned Chicago into a war zone. Visit the city's most dangerous areas.

What are the latest discoveries in the deadly world of asteroids? Will a recently returned Japanese spacecraft become the first to bring an asteroid sample back to our planet? What would happen to America's East Coast if the massive asteroid impact that helped form Chesapeake Bay 35 million years ago struck today? And why did President Barack Obama choose an asteroid as the destination for the next great manned mission into space? Learning about these huge space rocks isn't just about science, it's about survival.

Is mankind alone, or are there aliens out there, either waiting to be discovered, or on their way to find Earth? Professor Brian Cox spends this episode asking such questions, and what he discovers may raise a few eyebrows. He begins by exploring the human race's efforts to find neighbours in outer space, including the launch of two golden discs containing a greeting from Earth in the 1970s; they are still travelling and are now the most distant man-made objects from the planet. Brian also meets members of the Search for Extra-Terrestrial Intelligence, who have been monitoring radio signals for 50 years without success, before discussing the ingredients needed to make an intelligent civilisation with astrophysicist Dr Frank Drake.