Sagan discusses the story of the Heike crab and artificial selection of crabs resembling samurai warriors, as an opening into a larger discussion of evolution through natural selection (and the pitfalls of intelligent design). Among the topics are the development of life on the Cosmic Calendar and the Cambrian explosion; the function of DNA in growth; genetic replication, repairs, and mutation; the common biochemistry of terrestrial organisms; the creation of the molecules of life in the Miller-Urey experiment; and speculation on alien life (such as life in Jupiter's clouds). In the Cosmos Update ten years later, Sagan remarks on RNA also controlling chemical reactions and reproducing itself and the different roles of comets (potentially carrying organic molecules or causing the Cretaceous–Paleogene extinction event).

This episode explores the palaeogeography of Earth over millions of years, and its impact on the development of life on the planet. Tyson starts by explaining that the lignin-rich trees evolved in the Carboniferous era about 300 million ago, then explains on the nature of plate tectonics that would shape the landmasses of the world and the asteroid impact that initiated the Cretaceous–Paleogene extinction event, leaving small mammals as the dominate species on earth. Earth's landmasses are expected to change in the future and postulates what may be the next great extinction event.

Earth may seem like the most hospitable planet in the solar system. But look again. Startling new discoveries reveal the blue planet has been plagued by more chaos and destruction than scientists once imagined. Stand on the Earth billions of years ago as a primitive planet called Theia slams into it. Shiver as our entire globe is frozen over like a gigantic snowball. Feel the heat as mammoth volcanoes scorch the landscape and darken the sky. From a cosmic gamma ray burst frying away the ozone layer to an Everest-size asteroid slamming into the ocean, we'll reveal new information about how these unparalleled events drove life to the brink of total extinction. Out of this continuous devastation, how has our planet--and life--got to where it is today? Are the worst days behind us--or lurking in the distant future?

Imagine if one minute from now, every single person on Earth disappeared. All of us. Human history just stopped. What would happen to the world without us? Aftermath: Population Zero features what scientists and others speculate the earth, animal life, and plant life might be like if humanity no longer existed, as well as the effect that humanity's disappearance would have on the artefacts of civilization. this documentary is inspired by Alan Weisman's The World Without Us.

The theory of Némesis, a star that orbits the Sun and causes catastrophic events is explored. Nemesis is a hypothetical red dwarf or brown dwarf, originally postulated in 1984 to be orbiting the Sun at a distance of about 95,000 AU (1.5 light-years) somewhat beyond the Oort cloud, to explain a perceived cycle of mass extinctions in the geological record, which seem to occur more often at intervals of 26 million years.

The story begins with Tyson sitting at a campfire, and telling how the wolf changed through artificial selection, and selective breeding into the dog breeds around today. He then enters the Ship of Imagination, and explains natural selection with the process that helped to create the polar bears. Along the way he talks about DNA, genes and mutation. Next he goes to a forest and describes the Tree of life, this leads him to discussing the evolution of the eye. He then discusses extinction, by going to a monument called the Halls of Extinction, dedicated to the broken branches of the tree of life. Explaining the five great Extinction events. He then tells how some life has survived, and then focuses on the tardigrade. From there he talks about what other kinds of life might have been created on other worlds. He then goes to Saturn's moon Titan. From there he speculates about life and how it first began. He then returns to Earth and tells about abiogenesis and how life changed and evolved. The show ends with an animated sequence from the original series of life's evolution from one cell to humans.