We are in the grip of an allergy epidemic. 50 years ago one in 30 were affected, but in Britain today it is closer to one in three. Why this should be is one of modern medicine's greatest puzzles. In search of answers, Horizon travels round the globe, from the remotest inhabited island to the polluted centres of California and the UK. We meet sufferers and the scientists who have dedicated their lives trying to answer the mystery of why we are becoming allergic to our world.

Professor Jim Al-Khalili investigates one of the most important concepts in the world today - information. He discovers how we harnessed the power of symbols, everything from the first alphabet to the electric telegraph through to the modern digital age. But on this journey he learns that information isn't just about human communication, it's woven very profoundly into the fabric of reality.

The Cave of Swallows in Mexico is a 400m vertical shaft, deep enough to engulf the Empire State Building. The Lechuguilla cave system in the USA is 193km long and 500m deep with astonishing crystal formations hanging from its chambers. Although often overlooked, caves are remarkable habitats with equally bizarre wildlife. Cave angel fish cling to the walls behind cave waterfalls with microscopic hooks on their flattened fins. Cave swiftlets navigate by echo-location and build nests out of saliva. The Texas cave salamander has neither eyes nor pigment. Unique access to a hidden world of stalactites, stalagmites, snotites and troglodytes brings a wealth of surprises.

The Dutch Golden Age saw map-making reach a fever pitch of creative and commercial ambition. This was the era of the first ever Atlases - elaborate, lavish and beautiful. This was the great age of discovery and marked an unprecedented opportunity for mapmakers who sought to record and categorise the newly acquired knowledge of the world. Rising above the many mapmakers in this period was Gerard Mercator, inventor of the Mercator projection, who changed mapmaking forever when he published his collection of world maps in 1598 and coined the term 'Atlas'. The programme looks at some of the largest and most elaborate maps ever produced, from the vast maps on the floor of the Royal Palace in Amsterdam, to the 24 volume atlas covering just the Netherlands, to the largest Atlas in the world, The Klencke Atlas. It was made for Charles II to mark his restoration in 1660. But whilst being one of the British Libraries most important items, it is also one of its most fragile so hardly ever opened. This is a unique opportunity to see inside this enormous and lavish work, and see the world through the eyes of a King.

The episode begins with Tyson describing how pattern recognition manifested in early civilization as using astronomy and astrology to predict the passing of the seasons, including how the passage of a comet was often taken as an omen. Tyson continues to explain that the origin of comets only became known in the 20th century due to the work of Jan Oort and his hypothesis of the Oort cloud. Tyson then continues to relate the collaboration between Edmond Halley and Isaac Newton in the last part of the 17th century in Cambridge. The collaboration would result in the publication of Philosophiæ Naturalis Principia Mathematica, the first major work to describe the laws of physics in mathematical terms, despite objections and claims of plagiarism from Robert Hooke and financial difficulties of the Royal Society of London. Tyson explains how this work challenged the prevailing notion that God had planned out the heavens, but would end up influencing many factors of modern life, including space flight. Tyson further describes Halley's contributions including determining Earth's distance to the sun, the motion of stars and predicting the orbit of then-unnamed Halley's Comet using Newton's laws. Tyson contrasts these scientific approaches to understanding the galaxy compared to what earlier civilizations had done, and considers this advancement as mankind's first steps into exploring the universe. The episode ends with an animation of the Milky Way and Andromeda galaxies' merging based on the principles of Newton's laws.

East Africa is a land which is constantly changing. To survive here, creatures must be able to deal with unpredictable twists and turns - wet turning to dry, feast to famine, cold to hot - no matter how hostile it becomes. From dense forests to snow capped peaks, steamy swamps and endless savannah, this unique and varied land is also a haven for life, supporting large animals in numbers found nowhere else on Earth. But away from the familiar, forever-travelling herds, there are a huge cast of other characters - lizards that steal flies from the faces of lions, vast dinosaur-like birds who stalk catfish through huge wetlands, and an eagle who risks everything on the arrival of ten million bats from a far off rainforest.