Do you make your own luck, or does luck make you? Some scientists believe luck is strictly a matter of statistics and probabilities…but others believe unseen forces are at work, and randomness is built into every particle of the universe. We’ll find luck, good and bad, in casinos, basketball courts, genetics labs and the subatomic world. How much does the genetic lottery rule your fate? Are lucky streaks and unfortunate accidents merely our own minds fooling us? It’s a scientific journey that will radically revise your understanding of the laws of nature and the workings of the human brain.

Dr Michael Mosley traces the sinister ways the experimental psychology has used to try to control our minds. He finds that the pursuit of mind control has led to some truly horrific experiments and left many casualties in its wake. Extraordinary archive captures what happened - scientists systematically change the behaviour of children; law abiding citizens give fatal electric shocks; a gay man has electrodes implanted in his head in an attempt to turn his sexuality. Michael takes a hallucinogenic drug as part of a controlled experiment to try to understand how its mind-bending properties can change the brain. This is a scientific journey goes to the very heart of what we hold most dear - our free will, and our ability to control our own destiny.

Join investigators as they untangle the cause of Alzheimer’s and race to develop a cure. Alzheimer’s disease strikes at the core of what makes us human: our capacity to think, to love, and to remember. The disease ravages the minds of over 40 million victims worldwide, and it is one of the greatest medical mysteries of our time. Join investigators as they gather clues and attempt to reconstruct the molecular chain of events that ultimately leads to dementia". Follow key researchers in the field who have helped to develop the leading theories of the disease. Along the way, meet individuals from all walks of life who will reveal what it’s like to struggle with Alzheimer’s. Among them, members of a unique Colombian family who have learned that their genetic predisposition all but guarantees early onset Alzheimer’s. Yet there may be hope. Join these courageous patients participating in clinical trials, and then go behind the scenes of the major drug trials to see how researchers target and test therapies that may slow and even prevent Alzheimer’s

The idea of intelligence is explored in the concepts of computers (using bits as their basic units of information), whales (in their songs and their disruptions by human activities), DNA, the human brain (the evolution of the brain stem, frontal lobes, neurons, cerebral hemispheres, and corpus callosum under the Triune Brain Model), and man-made structures for collective intelligence (cities, libraries, books, computers, and satellites). The episode ends with speculation on alien intelligence and the information conveyed on the Voyager Golden Record.

We all agree lying is shameful. Yet we still deliberately deceive each other constantly. Are our brains wired for lying from a young age? The brains of pathological liars may provide insights. Will technology make it easier for us to be dishonest, or could it someday instantly reveal someone is lying? Perhaps we are deceitful because our limited senses prevent us from seeing the real truth. Scientists say our own memories deceive us, and have managed to implant false memories. Other scientists look for ultimate truth in the subatomic world … only to end up turning reality on its head.

This episodes the nature of the cosmos on the micro and atomic scales, using the Ship of the Imagination to explore these realms. Tyson describes some of the micro-organism that live within a dew drop, demonstrating parameciums and tardigrades. He proceeds to discuss how plants use photosynthesis via their chloroplasts to convert sunlight into chemical reactions that convert carbon dioxide and water into oxygen and energy-rich sugars. Tyson then discusses the nature of molecules and atoms and how they relate to the evolution of species. He uses the example set forth by Charles Darwin postulating the existence of the long-tongued Morgan's sphinx moth based on the nature of the comet orchid with pollen far within the flower. He further demonstrates that scents from flowers are used to trigger olfactory centers in the brain, stimulating the mind to threats as to aid in the survival of the species. Tyson narrates how Greek philosophers Thales and Democritus postulated that all matter was made up of combinations of atoms in a large number of configurations, and describes how carbon forms the basic building block for life on earth due to its unique chemical nature. Tyson explains on the basic atomic structure of protons, neutrons, and electrons, and the nature of nuclear fusion that occurs in most stars. He then discusses the existence of neutrinos that are created by these nuclear processes in stars, and that detecting such sub-atomic particles which normally pass through matter require subterranean facilities like the Super-Kamiokande that were used to detect neutrinos from the supernova SN 1987A in the Large Magellanic Cloud before light from the explosion were observed due to their ability to pass through matter of the dying sun. Tyson compares how neutrinos were postulated by Wolfgang Pauli to account for the conservation of energy from nuclear reactions in the same manner as Darwin's postulate on the long-tongued moth. Tyson concludes by noting that there are neutrinos from the Big Bang still existing in the universe but due to the nature of light, there is a "wall of infinity" that cannot be observed beyond.