Pluto is one of the Smaller than our own Moon, Pluto has never had a single visitor from Earth - until now. We keep saying, 'This is it, this is humanity's trip to Pluto. For the first time in human history, Pluto is about to be revealed. We can expect surprises, it's almost guaranteed. Until then, we can only guess what Pluto looks like. And recently, astronomers decided not to call it a planet any more. Once thought to be an isolated oddity, Pluto now marks the beginning of a whole new frontier. it's as if the explorers had climbed up to the top of the Rockies and were looking over and could see the lands of California on the other side. There has never been a better time to venture where no human has gone before. To follow in the footsteps of our robot pioneers and explore beyond the planets of our Solar System.

An exploration of Earth's cosmic neighbourhood. Looking beyond the borders of our solar system, what's nearby in our galaxy? How do the other objects in our local area influence life on Earth? And, how did Earth's place in the galaxy make it the perfect place for the development of advanced life? Now that the Voyagers have visited the outer planets of the solar system they are heading for new adventures in places astronomers call the Oort Cloud, the heliopause, heliosheath and eventually they may encounter double stars and exoplanets, some of which may pay a visit to the solar system one day or explode showering us with radiation. If the Voyagers live so long they will experience the local fluff, local bubble and other parts of the habitable zone of the galaxy.

The theory of Némesis, a star that orbits the Sun and causes catastrophic events is explored. Nemesis is a hypothetical red dwarf or brown dwarf, originally postulated in 1984 to be orbiting the Sun at a distance of about 95,000 AU (1.5 light-years) somewhat beyond the Oort cloud, to explain a perceived cycle of mass extinctions in the geological record, which seem to occur more often at intervals of 26 million years.

The episode begins with Tyson describing how pattern recognition manifested in early civilization as using astronomy and astrology to predict the passing of the seasons, including how the passage of a comet was often taken as an omen. Tyson continues to explain that the origin of comets only became known in the 20th century due to the work of Jan Oort and his hypothesis of the Oort cloud. Tyson then continues to relate the collaboration between Edmond Halley and Isaac Newton in the last part of the 17th century in Cambridge. The collaboration would result in the publication of Philosophiæ Naturalis Principia Mathematica, the first major work to describe the laws of physics in mathematical terms, despite objections and claims of plagiarism from Robert Hooke and financial difficulties of the Royal Society of London. Tyson explains how this work challenged the prevailing notion that God had planned out the heavens, but would end up influencing many factors of modern life, including space flight. Tyson further describes Halley's contributions including determining Earth's distance to the sun, the motion of stars and predicting the orbit of then-unnamed Halley's Comet using Newton's laws. Tyson contrasts these scientific approaches to understanding the galaxy compared to what earlier civilizations had done, and considers this advancement as mankind's first steps into exploring the universe. The episode ends with an animation of the Milky Way and Andromeda galaxies' merging based on the principles of Newton's laws.