At a crucial time in history, when religious violence is impacting peace all over the world, and science is venturing into areas that were once the realms of faith, Morgan Freeman embarks on a journey around the globe and through the centuries to uncover the Story of God. He will explore different cultures and religions on the ultimate quest to uncover the meaning of life, God and all these big questions in between. In the first episode, the actor examines religious belief. He starts by discussing the afterlife with scientists, scholars, a Hindu monk and a man who had a near-death experience.

The episode begins with Tyson describing how pattern recognition manifested in early civilization as using astronomy and astrology to predict the passing of the seasons, including how the passage of a comet was often taken as an omen. Tyson continues to explain that the origin of comets only became known in the 20th century due to the work of Jan Oort and his hypothesis of the Oort cloud. Tyson then continues to relate the collaboration between Edmond Halley and Isaac Newton in the last part of the 17th century in Cambridge. The collaboration would result in the publication of Philosophiæ Naturalis Principia Mathematica, the first major work to describe the laws of physics in mathematical terms, despite objections and claims of plagiarism from Robert Hooke and financial difficulties of the Royal Society of London. Tyson explains how this work challenged the prevailing notion that God had planned out the heavens, but would end up influencing many factors of modern life, including space flight. Tyson further describes Halley's contributions including determining Earth's distance to the sun, the motion of stars and predicting the orbit of then-unnamed Halley's Comet using Newton's laws. Tyson contrasts these scientific approaches to understanding the galaxy compared to what earlier civilizations had done, and considers this advancement as mankind's first steps into exploring the universe. The episode ends with an animation of the Milky Way and Andromeda galaxies' merging based on the principles of Newton's laws.

Is God worshipped in other worlds, across the cosmos? How might alien deities differ from our own? The answer may lie buried on Earth. Animal behaviorists are testing elephants and finding them capable of having spiritual thoughts. Artificial intelligence researchers are building enlightened robots that contemplate the divine. Meanwhile, cosmologists are looking for universal equations that could replace God. Have advanced aliens discovered everything there is to know about the universe? Or are they looking to a higher power for answers?

Humanity’s potential seems limitless. But could we become as powerful as God? Scientific breakthroughs grant our species seemingly divine abilities. Biologists tinkering with DNA are figuring out ways to grow new life forms, while neuroscientists try to create artificial consciousness. Statisticians around the world are using big data to predict the future and computer scientists have discovered a "God algorithm" that could solve any global problem in an instant. But to truly become God, we not only have to be all knowing, but all being. Quantum physicists are figuring out how to teleport matter at the speed of light!

Researchers discuss the possibility that the creation of the Large Hadron Collider was foretold in ancient sources that were inspired by aliens

Foo Fighters prepare to record at the Austin City Limits Studio, with blues guitarist Gary Clark, Jr. In this episode is examined the roots of Austin's music scene, with interviews featuring Billy Gibbons from ZZ Top, and Roky Erickson from 13th Floor Elevators, who is considered one of the American fathers of psychedelic rock. Dave also chats with Terry Lickona, the executive producer of Austin City Limits. The song 'What Did I Do? / God As My Witness' is recorded during this chapter.