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This episodes the nature of the cosmos on the micro and atomic scales, using the Ship of the Imagination to explore these realms. Tyson describes some of the micro-organism that live within a dew drop, demonstrating parameciums and tardigrades. He proceeds to discuss how plants use photosynthesis via their chloroplasts to convert sunlight into chemical reactions that convert carbon dioxide and water into oxygen and energy-rich sugars. Tyson then discusses the nature of molecules and atoms and how they relate to the evolution of species. He uses the example set forth by Charles Darwin postulating the existence of the long-tongued Morgan's sphinx moth based on the nature of the comet orchid with pollen far within the flower. He further demonstrates that scents from flowers are used to trigger olfactory centers in the brain, stimulating the mind to threats as to aid in the survival of the species. Tyson narrates how Greek philosophers Thales and Democritus postulated that all matter was made up of combinations of atoms in a large number of configurations, and describes how carbon forms the basic building block for life on earth due to its unique chemical nature. Tyson explains on the basic atomic structure of protons, neutrons, and electrons, and the nature of nuclear fusion that occurs in most stars. He then discusses the existence of neutrinos that are created by these nuclear processes in stars, and that detecting such sub-atomic particles which normally pass through matter require subterranean facilities like the Super-Kamiokande that were used to detect neutrinos from the supernova SN 1987A in the Large Magellanic Cloud before light from the explosion were observed due to their ability to pass through matter of the dying sun. Tyson compares how neutrinos were postulated by Wolfgang Pauli to account for the conservation of energy from nuclear reactions in the same manner as Darwin's postulate on the long-tongued moth. Tyson concludes by noting that there are neutrinos from the Big Bang still existing in the universe but due to the nature of light, there is a "wall of infinity" that cannot be observed beyond.

This episode is centered around how science, in particular the work of Clair Patterson (voiced in animated sequences by Richard Gere[33]) in the middle of the 20th century, has been able to determine the age of the Earth. Tyson first describes how the Earth was formed from the coalescence of matter some millions of years after the formation of the Sun, and while scientists can examine the formations in rock stratum to date some geological events, these can only trace back millions of years. Instead, scientists have used the debris from meteor impacts, such as the Meteor Crater in Arizona, knowing that the material from such meteors coming from the asteroid belt would have been made at the same time as the Earth. Patterson also examined the levels of lead in the common environment and in deeper parts of the oceans and Antarctic ice, showing that lead had only been brought to the surface in recent times. He would discover that the higher levels of lead were from the use of tetraethyllead in leaded gasoline resulting in government-mandated restrictions on the use of lead.

This episode provides an overview of the nature of electromagnetism, as discovered through the work of Michael Faraday. Tyson explains how the idea of another force of nature, similar to gravitational forces, had been postulated by Isaac Newton before. Tyson continues on Faraday, coming from poor beginnings, would end up becoming interested in studying electricity after reading books and seeing lectures by Humphry Davy at the Royal Institution. Davy would hire Faraday after seeing extensive notes he had taken to act as his secretary and lab assistant. After Davy and chemist William Hyde Wollaston unsuccessfully tried to build on Hans Christian Ørsted's discovery of the electromagnetic phenomena to harness the ability to create motion from electricity, Faraday was able to create his own device to create the first electric motor by applying electricity aligned along a magnet. Davy, bitter over Faraday's breakthrough, put Faraday on the task of improving the quality of high-quality optical glass, preventing Faraday from continuing his research. Faraday, undeterred, continued to work in the Royal Institution, and created the Christmas Lectures designed to teach science to children. Following Davy's death, Faraday returned to full time efforts studying electromagnetism, creating the first electrical generator by inserting a magnet in a coil of wires. Tyson continues to note that despite losing some of his mental capacity, Faraday concluded that electricity and magnetism were connected by unseen fields, and postulated that light may also be tied to these forces. Using a sample of the optical glass that Davy had him make, Faraday discovered that an applied magnetic field could affect the polarization of light passing through the glass sample (a dielectric material), leading to what is called the Faraday effect and connecting these three forces. Faraday postulated that these fields existed across the planet, which would later by called Earth's magnetic field generated by the rotating molten iron inner core, as well as the phenomena that caused the planets to rotate around the sun. Faraday's work was initially rejected by the scientific community due to his lack of mathematical support, but James Clerk Maxwell would later come to rework Faraday's theories into the Maxwell's equations that validated Faraday's theories. Their combined efforts created the basis of science that drives the principles of modern communications today.

This episode covers the nature of how life may have developed on Earth and the possibility of life on other planets. Tyson begins by explaining how the human development of writing systems enabled the transfer of information through generations, describing how Princess Enheduanna ca. 2280 BCE would be one of the first to sign her name to her works, and how Gilgamesh collected stories, including that of Utnapishtim documenting a great flood comparable to the story of Noah's Ark. Tyson explains how DNA similarly records information to propagate life, and postulates theories of how DNA originated on Earth, including evolution from a shallow tide pool, or from the ejecta of meteor collisions from other planets. In the latter case, Tyson explains how comparing the composition of the Nakhla meteorite in 1911 to results collected by the Viking program demonstrated that material from Mars could transit to Earth, and the ability of some microbes to survive the harsh conditions of space. With the motions of solar systems through the galaxy over billions of years, life could conceivably propagate from planet to planet in the same manner. Tyson then moves on to consider if life on other planets could exist. He explains how Project Diana performed in the 1960s showed that radio waves are able to travel in space, and that all of humanity's broadcast signals continue to radiate into space from our planet. Tyson notes that projects have since looked for similar signals potentially emanating from other solar systems. Tyson then explains that the development and lifespan of extraterrestrial civilizations must be considered for such detection to be realized. He notes that civilizations can be wiped out by cosmic events like supernovae, natural disasters such as the Toba disaster, or even self-destruct through war or other means, making probability estimates difficult. Tyson describes how elliptical galaxies, in which some of the oldest red dwarf stars exist, would offer the best chance of finding established civilizations. Tyson concludes that human intelligence properly applied should allow our species to avoid such disasters and enable us to migrate beyond the Earth before the Sun's eventual transformation into a red giant.

Tyson describes the discovery of cosmic rays by Victor Hess through high-altitude balloon trips. Swiss Astronomer Fritz Zwicky, in studying supernovae, postulated that these cosmic rays originated from these events instead of electromagnetic radiation. Also tells how Vera Rubin observed that the rotation of stars at the edges of observable galaxies did not follow expected rotational behavior leading to consider the existence of dark matter. This further led to the discovery of dark energy to account for the increasing rate of expansion of the universe. Tyson then describes the interstellar travel of the two Voyager probes. Tyson tells the Carl Sagan's role in the Voyager program, including creating the Voyager Golden Record to encapsulate humanity and Earth's position in the universe. Tyson concludes the series by emphasizing Sagan's message on the human condition in the vastness of the cosmos, and to encourage viewers to continue to explore and discover what else the universe has to offer.

Professor Jim Al-Khalili investigates the most accurate and yet perplexing scientific theory ever - quantum physics. At the beginning of the 20th century scientists were led into the hidden workings of matter, into the sub-atomic building blocks of the world around us. They discovered phenomena unlike any encountered before - a realm where things can be in many places at once, where chance and probability call the shots and where reality appears to only truly exist when we observe it. Albert Einstein hated the idea that nature, at its most fundamental level, is governed by chance. Jim reveals how, in the 1930s, Einstein thought he'd found a fatal flaw in quantum physics because it implies that sub-atomic particles can communicate faster than light in defiance of the theory of relativity. In the 1960s the scientist John Bell showed there was a way to test if Einstein was right and quantum mechanics was actually mistaken. Jim repeats this critical experiment - with shocking results.