An epic documentary film in which nine scientists will meet in a chain of encounters to uncover unexpected answers to some of humanity's biggest questions. How did life begin? What is time? What is consciousness? How much do we really know? By introducing researchers from diverse backgrounds for the first time, then dropping them into new, immersive field work they previously hadn't tackled, the film reveals the true potential of interdisciplinary collaboration, pushing the boundaries of how science storytelling is approached.
What emerges is a deeply human trip to the foundations of discovery and a powerful reminder that the unanswered questions are the most crucial ones to pose. The Most Unknown is an ambitious look at a side of science.

'It's really about terror and intimidation and people basically fighting for survival and often committing extraordinary violence in order to protect themselves or to stay safe. It's kind of like the weak dog in the pack. If others spot weakness, they're gonna pounce on you for a couple of reasons. You pounce on that guy, that gives you a little more status. So, I had to ask myself, are you gonna be a victim? No, I ain't gonna be a victim. Well, that really only left me one choice in my mind. That means I gotta be the victimizer. At some point, for some reason, might be legitimate, might not be, someone's gonna test you.. Even if you lose, you're gonna have to stand up for yourself. '
'A guy comes over, and it's your day to get your package, and he tries to take your package from you that your people sent you, if you let him do it, there's gonna be 10 other dudes, oh, yeah, he let that guy take his package, I'm gonna go get his TV, right down the line until somebody's after your ass. But if you stand up that first time and they see you'll stand up for yourself, even if you lose, people will respect that. Oh, don't mess with him. There's easier prey. Why do you have to go and get that guy and get a couple lumps for it when he can go get that guy's stuff over there, don't cost you nothing. It usually only has to happen once or twice but just as importantly that you didn't go to the man for help... you're gonna be all right.'

What makes us human is the squishy triple-pounder inside our heads. It lets us build skyscrapers, and lift a special few of us into space. We are the only species on this planet that can construct realities in our mind and then go actually build it. The story of how our mind evolved on this one strange rock is one of chance, coincidence and impossible odds.
This episode is an investigation into the mystery of the human brain and the chain of events that produced the anomaly of human intelligence.

Two and a half thousand years ago, the Greek philosopher Socrates worried that the wide use of writing would have a negative impact on people's minds. He said that writing would create forgetfulness, because people will not use their memories. They would trust the external written characters and not remember themselves. In a world with an ever-growing tech industry, Michael Stevens tries to find out what effect technology has on our brains. He finds Technology isn't just changing our lives, it's changing our brains. In his experiments he tests what just 10 days of gaming does to things like our spatial memory.

A hero is just someone who acts selflessly, out of concern for others, at personal risk and without the expectation of reward. In this episode, Michael Stevens asks employees to help him run a seemingly dangerous experiment, to see if they would blow the whistle to stop him.

Autistic minds provide windows into how we all think, feel, and behave. A complete brain science should be able to account for all kinds of minds and brains. As long as some minds remain a mystery, so too will all minds.
Michael Stevens travels to London to meet a blind, autistic savant with astonishing musical abilities, and volunteers to have his brain's function temporarily disrupted at UCLA's Neuromodulation Lab.