Questions are raised about the search for intelligent life beyond the Earth, with UFOs and other close encounters refuted in favor of communications through SETI and radio telescope such as the Arecibo Observatory. The probability of technically advanced civilizations existing elsewhere in the Milky Way is interpreted using the Drake equation and a future hypothetical Encyclopedia Galactica is discussed as a repository of information about other worlds in the galaxy. The Cosmos Update notes that there have been fewer sightings of UFOs and more stories of abductions, while mentioning the META scanning the skies for signals.

Sagan reflects on the future of humanity and the question of 'who speaks for Earth?' when meeting extraterrestrials. He discusses the very different meetings of the Tlingit people and explorer Jean-François de La Perouse with the destruction of the Aztecs by Spanish conquistadors, the looming threat of nuclear warfare, and the threats shown by destruction of the Library of Alexandria and the murder of Hypatia. The episode ends with an overview of the beginning of the universe, the evolution of life, and the accomplishments of humanity and makes a plea to mankind to cherish life and continue its journey in the cosmos. The Cosmos Update notes the preliminary reconnaissance of planets with spacecraft, the fall of the Berlin Wall and the end of apartheid in South Africa, and measures towards the reduction of nuclear weapons.

In this documentary we moved to Ancient Egypt to learn their vision of the world, life and death, gods and magic. For the ancient Egyptians, the Nile was the main connection between their lives and an infinite supply of provisions. But its waters hid an underworld of darkness and mystery for its first settlers. The Nile was one the spiritual paths that combined life and death, the real world and the underworld.

Richard Dawkins examines the growing suspicion the public has for science-based medicine, despite its track record of successes like the germ theory of disease, vaccines, antibiotics and increased lifespan. He notes a fifth of British children are currently not immunised against measles, mumps and rubella, attributing it to fears arising from a highly controversial report linking the vaccine with autism. Dawkins criticizes the growing field of alternative medicine which does not pass the same objective and statistical rigour as scientifically derived treatments using controlled double-blind studies. Without verifiable evidence, alternative therapies must rely on biased anecdotes and word of mouth to perpetuate. Dawkins observes these treatments have fanciful rationales and rituals behind them, with many alternative treatments employing pseudoscientific jargon such as "energy", "vibration" or "quantum theory" to give themselves greater credence to patients.

Dr Adam Rutherford tells the extraordinary story of the scientific quest to discover the secrets of the cell and of life itself. Every living thing is made of cells, microscopic building blocks of almost unimaginable power and complexity. The first part explores how centuries of scientific and religious dogma were overturned by the earliest discoveries of the existence of cells, and how scientists came to realize that there was, literally, more to life than meets the eye.

This episode explores how scientists delved ever deeper into the world of the cell, seeking to reveal the magic ingredient that can spark a bundle of chemicals into life. Their discoveries have brought us to the brink of being able to create life for ourselves.